7312-14-3

Basic information

• Product Name: 5-BROMO-1-BENZOTHIOPHENE-2-CARBONYL CHLORIDE
• Synonyms: 5-BROMO-1-BENZOTHIOPHENE-2-CARBONYL CHLORIDE
• CAS NO: 7312-14-3
• Molecular Formula: C9H4BrClOS
• Molecular Weight: 275.55
• Mol File: 7312-14-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 364.8°C at 760 mmHg
• Flash Point: 174.4°C
• Appearance: /
• Density: 1.77g/cm³
• Vapor Pressure: 1.64E-05mmHg at 25°C
• Refractive Index: 1.704
• CAS DataBase Reference: 5-BROMO-1-BENZOTHIOPHENE-2-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-1-BENZOTHIOPHENE-2-CARBONYL CHLORIDE(7312-14-3)
• EPA Substance Registry System: 5-BROMO-1-BENZOTHIOPHENE-2-CARBONYL CHLORIDE(7312-14-3)

Safety Data

• Hazardous Substances Data: 7312-14-3(Hazardous Substances Data)

Usage

Description

5-BROMO-1-BENZOTHIOPHENE-2-CARBONYL CHLORIDE is a chemical compound with the molecular formula C10H5BrClOS. It is a benzothiophene derivative that has a carbonyl chloride functional group attached to the 2-position of the benzothiophene ring.
Used in Pharmaceutical Industry:
5-BROMO-1-BENZOTHIOPHENE-2-CARBONYL CHLORIDE is used as a reagent for the introduction of the benzothiophene-2-carbonyl chloride group into organic molecules. It is commonly used in the synthesis of various drugs and drug intermediates.
Used in Materials Science:
5-BROMO-1-BENZOTHIOPHENE-2-CARBONYL CHLORIDE has potential applications in the field of materials science.
Used in Agrochemicals:
5-BROMO-1-BENZOTHIOPHENE-2-CARBONYL CHLORIDE also has potential applications in the field of agrochemicals.
Note: 5-BROMO-1-BENZOTHIOPHENE-2-CARBONYL CHLORIDE is sensitive to air, moisture, and light, and should be handled and stored under inert atmosphere and low temperatures.

InChI:InChI=1/C9H4BrClOS/c10-6-1-2-7-5(3-6)4-8(13-7)9(11)12/h1-4H

Upstream product

• 7312-10-9 5-bromo-1-benzothiophene-2-carboxylic acid 

Relevant articles and documents

STAT DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase

Deoxyhypusine synthase (DHPS) utilizes spermidine and NAD as cofactors to incorporate a hypusine modification into the eukaryotic translation initiation factor 5A (eIF5A). Hypusine is essential for eIF5A activation, which, in turn, plays a key role in regulating protein translation of selected mRNA that are associated with the synthesis of oncoproteins, thereby enhancing tumor cell proliferation. Therefore, inhibition of DHPS is a promising therapeutic option for the treatment of cancer. To discover novel lead compounds that target DHPS, we conducted synthetic studies with a hit obtained via high-throughput screening. Optimization of the ring structures of the amide compound (2) led to bromobenzothiophene (11g) with potent inhibitory activity against DHPS. X-ray crystallographic analysis of 11g complexed with DHPS revealed a dramatic conformational change in DHPS, which suggests the presence of a novel allosteric site. These findings provide the basis for the development of novel therapy distinct from spermidine mimetic inhibitors.

SMALL MOLECULE DEGRADERS OF STAT3

The present disclosure provides compounds represented by Formula I or Formula VIII: wherein R1a, R1b, M, A, E, QA, and QB are as defined in the specification, and the salts and solvates thereof. Compounds of Formula I are degraders of STAT3 or dedraders of STAT3 and STAT1. Compounds of Formula VIII are inhibitors of STAT3. STAT3 degraders and inhibitors are useful for the treatment of cancer and other diseases.