73217-34-2 Usage
Chemical structure
A heterocyclic compound containing an oxadiazole ring, a chlorine-methyl group, and a methylphenyl group attached to the oxadiazole ring.
Molecular weight
Approximately 216.62 g/mol
Functional groups
Oxadiazole ring, chlorine-methyl group, and methylphenyl group.
Pharmaceuticals
Due to its unique structure and potential biological activities.
Agrochemicals
For similar reasons as in pharmaceuticals.
Materials science
Possible utility in the development of new materials.
Organic synthesis
As a building block or intermediate in the synthesis of other compounds.
Research status
Further research is needed to fully understand its properties and potential uses.
Reactivity
The presence of the chlorine-methyl group may make the compound reactive towards nucleophiles, leading to the formation of various derivatives.
Stability
The compound's stability may depend on factors such as temperature, solvent, and the presence of other reactive species.
Solubility
The compound's solubility profile is not provided, but it may be influenced by the polarity of the oxadiazole ring and the chlorine-methyl group.
Safety and handling
As with any chemical, appropriate safety measures should be taken when handling 1,2,4-Oxadiazole, 3-(chloromethyl)-5-(2-methylphenyl)-, including the use of personal protective equipment and proper disposal methods.
Check Digit Verification of cas no
The CAS Registry Mumber 73217-34-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,2,1 and 7 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 73217-34:
(7*7)+(6*3)+(5*2)+(4*1)+(3*7)+(2*3)+(1*4)=112
112 % 10 = 2
So 73217-34-2 is a valid CAS Registry Number.
73217-34-2Relevant articles and documents
Novel N-Substituted oseltamivir derivatives as potent influenza neuraminidase inhibitors: Design, synthesis, biological evaluation, ADME prediction and molecular docking studies
Ye, Jiqing,Yang, Xiao,Xu, Min,Chan, Paul Kay-sheung,Ma, Cong
, (2019/09/06)
The discovery of novel potent neuraminidase (NA) inhibitors remains an attractive approach for treating infectious diseases caused by influenza. In this study, we describe the design and synthesis of novel N-substituted oseltamivir derivatives for probing the 150-cavity which is nascent to the activity site of NA. NA inhibitory studies showed that new derivatives demonstrated the inhibitory activity with IC50 values at nM level against NA of a clinical influenza virus strain. Moreover, the in silico ADME predictions showed that the selected compounds had comparable properties with oseltamivir carboxylate, which demonstrated the druggablity of these derivatives. Furthermore, molecular docking studies showed that the most potent compound 6f and 10i could adopt different modes of binding interaction with NA, which may provide novel solutions for treating oseltamivir-resistant influenza. Based on the research results, we consider that compounds 6f and 10i have the potential for further studies as novel antiviral agents.
