7333-63-3Relevant articles and documents
A diketopyrrolopyrrole-based fluorescent probe for investigating mitochondrial zinc ions
Du, Chenchen,Fu, Shibo,Ren, Xiaolei,Wang, Xiaohua,Wang, Zhong,Zhou, Juan,Wang, Hongyu
, p. 3493 - 3502 (2018)
We demonstrate a strategy to asymmetrically introduce a Zn2+ chelator (MeO-DPEN) and a mitochondrial-targeting group (TPP) at the N-positions of both lactam moieties of diketopyrrolopyrrole (DPP) fluorophore. And two probes DPP-Mito and DPP-C2
A mitochondria-targeted thiazoleorange-based photothermal agent for enhanced photothermal therapy for tumors
Bian, Wangqing,Pan, Zhenxing,Wang, Yakun,Long, Wei,Chen, Zefeng,Chen, Niping,Zeng, Yaoxun,Yuan, Jiongpeng,Liu, Xujie,Lu, Yu-Jing,He, Yan,Zhang, Kun
, (2021)
Organic small molecules with near-infrared (NIR) absorption hold great promise as the phototheranostic agents for clinical translation by virtue of their inherent merits such as well-defined chemical structure, high purity and good reproducibility. Probes
Fluorescent Probe HKSOX-1 for imaging and detection of endogenous superoxide in live cells and in vivo
Hu, Jun Jacob,Wong, Nai-Kei,Ye, Sen,Chen, Xingmiao,Lu, Ming-Yang,Zhao, Angela Qian,Guo, Yuhan,Ma, Alvin Chun-Hang,Leung, Anskar Yu-Hung,Shen, Jiangang,Yang, Dan
, p. 6837 - 6843 (2015)
Superoxide anion radical (O2-) is undoubtedly the most important primary reactive oxygen species (ROS) found in cells, whose formation and fate are intertwined with diverse physiological and pathological processes. Here we report a highly sensitive and selective O2- detecting strategy involving O2- cleavage of an aryl trifluoromethanesulfonate group to yield a free phenol. We have synthesized three new O2- fluorescent probes (HKSOX-1, HKSOX-1r for cellular retention, and HKSOX-1m for mitochondria-targeting) which exhibit excellent selectivity and sensitivity toward O2- over a broad range of pH, strong oxidants, and abundant reductants found in cells. In confocal imaging, flow cytometry, and 96-well microplate assay, HKSOX-1r has been robustly applied to detect O2- in multiple cellular models, such as inflammation and mitochondrial stress. Additionally, our probes can be efficiently applied to visualize O2- in intact live zebrafish embryos. These probes open up exciting opportunities for unmasking the roles of O2- in health and disease.
Two Are Better Than One: A Design Principle for Ultralong-Persistent Luminescence of Pure Organics
Alam, Parvej,Leung, Nelson L. C.,Liu, Junkai,Cheung, Tsz Shing,Zhang, Xuepeng,He, Zikai,Kwok, Ryan T. K.,Lam, Jacky W. Y.,Sung, Herman H. Y.,Williams, Ian D.,Chan, Christopher C. S.,Wong, Kam Sing,Peng, Qian,Tang, Ben Zhong
, (2020/05/06)
Because of their innate ability to store and then release energy, long-persistent luminescence (LPL) materials have garnered strong research interest in a wide range of multidisciplinary fields, such as biomedical sciences, theranostics, and photonic devices. Although many inorganic LPL systems with afterglow durations of up to hours and days have been reported, organic systems have had difficulties reaching similar timescales. In this work, a design principle based on the successes of inorganic systems to produce an organic LPL (OLPL) system through the use of a strong organic electron trap is proposed. The resulting system generates detectable afterglow for up to 7 h, significantly longer than any other reported OLPL system. The design strategy demonstrates an easy methodology to develop organic long-persistent phosphors, opening the door to new OLPL materials.
A SET OF MITOCHONDRIA-TARGETED COMPOUNDS
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Page/Page column 11, (2019/01/17)
Here are described SkQ compounds containing cations of various types: alkyl(triphenyl)phosphonium cation, quaternary ammonium cations, including pH -dependent and permanent cations of rhodamines, berberine and palmatine alkaloids.
