736143-51-4

Basic information

• Product Name: methyl (2',3',5,6-tetramethoxybiphenyl-2-yl)acetate
• Synonyms: methyl (2',3',5,6-tetramethoxybiphenyl-2-yl)acetate
• CAS NO: 736143-51-4
• Molecular Weight: 346.38
• Mol File: 736143-51-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl (2',3',5,6-tetramethoxybiphenyl-2-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2',3',5,6-tetramethoxybiphenyl-2-yl)acetate(736143-51-4)
• EPA Substance Registry System: methyl (2',3',5,6-tetramethoxybiphenyl-2-yl)acetate(736143-51-4)

Safety Data

• Hazardous Substances Data: 736143-51-4(Hazardous Substances Data)

Upstream product

• 40972-86-9 (2,3-dimethoxyphenyl)boronic acid 

Relevant articles and documents

The palladium(0) Suzuki cross-coupling reaction as the key step in the synthesis of aporphinoids

We report a flexible approach to the total synthesis of 4,5-dioxoaporphines based on the palladium(0) catalyzed Suzuki cross-coupling of phenylboronic acids with sterically hindered 2-bromo phenyl acetates or bromo phenyl acetamides, followed by sequential bicyclization of biarylacetamides promoted by oxalyl chloride/Lewis acid. The reduction of 4,5-dioxoaporphines provides a chemoselective entry to aporphines, dehydroaporphines and 4-hydroxy- dehydroaporphines. A three-steps total synthesis for (±)-O,O′- dimethylapomorphine from readily accessible precursors is also reported.