73735-22-5

Basic information

• Product Name: 3H-Imidazo[4,5-b]pyridin-2-amine, 3-(phenylmethyl)-N-[1-(2-propenyl)-4-piperidinyl]-
• CAS NO: 73735-22-5
• Molecular Formula: C21H25N5
• Molecular Weight: 347.463
• Mol File: 73735-22-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3H-Imidazo[4,5-b]pyridin-2-amine, 3-(phenylmethyl)-N-[1-(2-propenyl)-4-piperidinyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-Imidazo[4,5-b]pyridin-2-amine, 3-(phenylmethyl)-N-[1-(2-propenyl)-4-piperidinyl]-(73735-22-5)
• EPA Substance Registry System: 3H-Imidazo[4,5-b]pyridin-2-amine, 3-(phenylmethyl)-N-[1-(2-propenyl)-4-piperidinyl]-(73735-22-5)

Safety Data

• Hazardous Substances Data: 73735-22-5(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 32282-07-8 N²-benzyl-2,3-pyridinediamine 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 73733-83-2 ethyl 4-[{[{2-[(phenylmethyl)amino]-3-pyridinyl}amino]thioxomethyl}amino]-1-piperidinecarboxylate 
• 73734-02-8 ethyl 4-[3-(phenylmethyl)-3H-imidazo[4,5-b]pyridin-2-ylamino]-1-piperidinecarboxylate 
• 3723-70-4 benzyl-(3-nitro-pyridin-2-yl)-amine 
• 6728-21-8 allyl mesylate 
• 76031-50-0 3-(phenylmethyl)-N-(4-piperidinyl)-3H-imidazo[4,5-b]pyridin-2-amine 

Relevant articles and documents

New Antihistaminic N-Heterocyclic 4-Piperidinamines. 3. Synthesis and Antihistaminic Activity of N-(4-Piperidinyl)-3H-imidazopyridin-2-amines

To study the bioisosteric replacement of a 2-pyridyl ring for a phenyl nucleus in astemizole, a series of N-(4-piperidinyl)-3H-imidazopyridin-2-amines was synthesised and evaluated.The title compounds were obtained starting from either 8a or 8b by four synthetic methods.The in vivo antihistamine activity was evaluated by the compound 48/80-induced lethality test in rats and the histamine-induced lethality test in guinea pigs after oral and/or subcutaneous administration.Compound 37, the isostere of astemizole, showed the most potent antihistaminic properties in the rat.However, astemizole is superior to 37 as to duration of action and total potency.