7377-26-6

Basic information

• Product Name: Methyl 4-chlorocarbonylbenzoate
• Synonyms: METHYL 4-CHLOROFORMYLBENZOATE;METHYL 4-CHLOROCARBONYLBENZOATE;4-(CHLOROCARBONYL)-BENZOIC ACID METHYL ESTER;4-CHLOROFORMYLBENZOIC ACID METHYL ESTER;TEREPHTALEIC ACID MONOMETHYL ESTER CHLORIDE;TEREPHTHALIC ACID MONOMETHYL ESTER CHLORIDE;TIMTEC-BB SBB005801;TEREPHTALIC ACID MONOMETHYL ESTER CHLORIDE
• CAS NO: 7377-26-6
• Molecular Formula: C₉H₇ClO₃
• Molecular Weight: 198.6
• EINECS: 230-937-2
• Product Categories: APIs Intermediate;Benzoic acid
• Mol File: 7377-26-6.mol
• Article Data: 115

Chemical Properties

• Melting Point: 50-59 °C
• Boiling Point: 140 °C / 15mmHg
• Flash Point: 127.3 °C
• Appearance: Off-white to light yellow/Crystalline Powder
• Density: 1.3219 (rough estimate)
• Vapor Pressure: 0.00191mmHg at 25°C
• Refractive Index: 1.5230 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: HYDROLYSIS
• Water Solubility: HYDROLYSIS
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: Methyl 4-chlorocarbonylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-chlorocarbonylbenzoate(7377-26-6)
• EPA Substance Registry System: Methyl 4-chlorocarbonylbenzoate(7377-26-6)

Safety Data

• Hazard Codes: C
• Statements: 34-22
• Safety Statements: 24/25-45-36/37/39-26
• RIDADR: 3261
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: Ⅲ
• Hazardous Substances Data: 7377-26-6(Hazardous Substances Data)

Usage

Description

Methyl 4-chlorocarbonylbenzoate, also known as 4-(Chlorocarbonyl)benzoic acid methyl ester, is an organic compound that serves as a versatile building block in the synthesis of various pharmaceutical compounds. It is characterized by the presence of a chlorocarbonyl group and a methyl ester group, which contribute to its reactivity and potential applications in the chemical and pharmaceutical industries.

Uses

Used in Pharmaceutical Industry:
Methyl 4-chlorocarbonylbenzoate is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the formation of diverse chemical entities with potential therapeutic applications.
Used in Benzophenone Residue Preparation:
Methyl 4-chlorocarbonylbenzoate is used as a precursor in the preparation of benzophenone residues. Benzophenones are a class of compounds that have found applications in various fields, including pharmaceuticals, agrochemicals, and materials science.
Used in Synthesis of Novel Bulky Hydrophobic Retinoids:
Methyl 4-chlorocarbonylbenzoate is utilized in the synthesis of novel bulky hydrophobic retinoids. These retinoid compounds have potential applications in the treatment of various skin disorders and conditions, as well as in cosmetic formulations. The unique structure of Methyl 4-chlorocarbonylbenzoate allows for the development of innovative and effective retinoid-based therapies.

InChI:InChI=1/C9H7ClO3/c1-13-9(12)7-4-2-6(3-5-7)8(10)11/h2-5H,1H3

Upstream product

• 1679-64-7 Monomethyl terephthalate 
• 13188-55-1 4-hydrazinocarbonylbenzoic acid methyl ester 
• 67-56-1 methanol 
• 100-20-9 terephthaloyl chloride 
• 120-61-6 1,4-benzenedicarboxylic acid dimethyl ester 
• 4091-02-5 vinyl methyl terephthalate 
• 100-21-0 terephthalic acid 
• 1571-08-0 methyl 4-formylbenzoate 
• 42967-55-5 monomethyl monopotassium terephthalate 
• 17874-79-2 pyridine-2,5-dicarboxylic acid 5-methyl ester 
• 1147550-11-5 ammonium thiocyanate 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 17763-71-2 4-carbomethoxyphenyl triflate 
• 141-75-3 butyryl chloride 

Downstream Products

• 22744-13-4 4-(2-diazoacetyl)benzoic acid methyl ester 
• 20093-73-6 terephthalic acid-(2-acetyl-phenyl ester)-methyl ester 
• 6724-91-0 N,N'-hexanediyl-bis-terephthalamic acid dimethyl ester 
• 5611-81-4 1,4-bis[2-[[4-(methoxycarbonyl) benzoyl]oxy]ethyl] 1,4-benzenedicarboxylate 
• 27239-22-1 methyl bis(2-hydroxyethyl) terephthalate 
• 2225-04-9 O,O'-(ethane-1,2-diyl)dimethyl diterephthalate 
• 102810-33-3 N,N'-bis-(4-methoxycarbonylbenzoyl)-1,4-butanediamine 
• 855293-47-9 4-(2,4-dimethyl-benzoyl)-benzoic acid 
• 35776-96-6 4-(4'-methylbenzoyl)benzoic acid 
• 7333-86-0 N-octadecyl-terephthalamic acid methyl ester 
• 611-95-0 4-carboxybenzophenone 
• 173458-34-9 4-azidocarbonyl-benzoic acid methyl ester 
• 40873-09-4 C₁₉H₁₆Cl₂N₂O₄ 
• 40873-10-7 C₂₀H₁₈Cl₂N₂O₄ 

Relevant articles and documents

Synthesis and fluorescence properties of environment-sensitive 7-(diethylamino)coumarin derivatives

By linking 7-(diethylamino)coumarin and different aromatic groups via an oxazole moiety, a small series of new environment-sensitive fluorophores have been synthesized. They display varying degrees of environment-sensitivity, depending on the aromatic gro

One-step Conversion of Amides and Esters to Acid Chlorides with PCl3

A general and efficient iodine-promoted chlorination of amides and esters with phosphorus trichloride is described. For the first time. Various inactivated amides including secondary and tertiary amides were directly converted to the corresponding acid chlorides in one-step. The substrate scope of methyl esters including aromatic and aliphatic esters was also explored under this system. This method is simple, scalable and wide in scope, which provides an approach to preparation of these acid chlorides.

sEH inhibitor and preparation method and application thereof

The invention provides an sEH inhibitor and a preparation method and application thereof, and relates to the technical field of endogenous active substance regulation and control. The sEH inhibitor provided by the invention has a structure as shown in a f

An efficient synthesis of a 6″-BODIPY-α-Galactosylceramide probe for monitoring α-Galactosylceramide uptake by cells

Herein, an efficient synthesis of BODIPY-α-Galactosylceramide 3, which can be used to study the cellular uptake of the potent immunostimulatory parent compound α-Galactosylceramide, is reported. Key in our synthetic strategy is the six-step synthesis of the core BODIPY scaffold (64% yield overall) and its quantitative conversion to an N-hydroxysuccinimidyl ester to facilitate conjugation and purification of the target glycolipid. For the preparation of the core of the glycolipid, the solubility of the lipid acceptor proved to be critical. The ability of BODIPY-αGalCer 3 to activate invariant natural killer cells was then demonstrated in vitro.