73839-06-2

Basic information

• Product Name: 3-Amino-3-Methylpiperidine-2,6-Dione Hydrochloride
• Synonyms: 3-Amino-3-Methylpiperidine-2,6-Dione Hydrochloride;3-Amino-3-Methylpiperidine-2,6-Dione Hydrochloride(WXC01479)
• CAS NO: 73839-06-2
• Molecular Formula: C₆H₁₀N₂O₂*ClH
• Molecular Weight: 178.61674
• Mol File: 73839-06-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Amino-3-Methylpiperidine-2,6-Dione Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-3-Methylpiperidine-2,6-Dione Hydrochloride(73839-06-2)
• EPA Substance Registry System: 3-Amino-3-Methylpiperidine-2,6-Dione Hydrochloride(73839-06-2)

Safety Data

• Hazardous Substances Data: 73839-06-2(Hazardous Substances Data)

Usage

Description

3-Amino-3-Methylpiperidine-2,6-Dione Hydrochloride is a chemical compound with the formula C6H10N2O2·HCl. It is a white to off-white crystalline powder that is soluble in water, ethanol, and methanol. 3-Amino-3-Methylpiperidine-2,6-Dione Hydrochloride is primarily used as a building block in the synthesis of various biologically active compounds, such as drugs and agrochemicals. It also serves as an intermediate in the production of catalysts and other specialty chemicals.

Uses

Used in Pharmaceutical Industry:
3-Amino-3-Methylpiperidine-2,6-Dione Hydrochloride is used as a reactant in the synthesis of pharmaceuticals for its ability to contribute to the formation of biologically active compounds. Its presence in the synthesis process aids in creating drugs with specific therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical industry, 3-Amino-3-Methylpiperidine-2,6-Dione Hydrochloride is used as a building block in the synthesis of various agrochemicals. It plays a crucial role in developing compounds that help protect crops and enhance agricultural productivity.
Used in Catalyst Production:
3-Amino-3-Methylpiperidine-2,6-Dione Hydrochloride is used as an intermediate in the production of catalysts. Its chemical properties make it suitable for参与 the creation of catalysts that can accelerate chemical reactions in various industrial processes.
Used in Specialty Chemicals:
3-Amino-3-Methylpiperidine-2,6-Dione Hydrochloride is also utilized in the synthesis of specialty chemicals, where its unique structure and reactivity contribute to the development of high-value products for specific applications in industries such as coatings, adhesives, and more.

Upstream product

• 903890-66-4 3-[benzylideneamino]-3-methylpiperidine-2,6-dione 
• 73839-04-0 3-Amino-3-methyl-4,5-dehydropiperidine-2,6-dione monohydrochloride 
• 202271-73-6 N-benzyloxycarbonyl-α-amino-α-methylglutarimide 
• 17115-06-9 Cbz-α-methylglutamic acid anhydride 
• 73839-03-9 3-(Benzylideneamino)-3-methyl-4,5-dehydropiperidine-2,6-dione 
• 73839-05-1 2-(Benzylideneamino)glutarimide 
• 24666-55-5 3-(benzyloxycarbonyl)-amino-2,6-dioxopiperidine 

Downstream Products

• 444288-88-4 4-(3-Chloro-benzylamino)-2-(3-methyl-2,6-dioxo-piperidin-3-yl)-isoindole-1,3-dione 

Relevant articles and documents

Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma

Many patients with multiple myeloma (MM) initially respond to treatment with modern combination regimens including immunomodulatory agents (lenalidomide and pomalidomide) and proteasome inhibitors. However, some patients lack an initial response to therapy (i.e., are refractory), and although the mean survival of MM patients has more than doubled in recent years, most patients will eventually relapse. To address this need, we explored the potential of novel cereblon E3 ligase modulators (CELMoDs) for the treatment of patients with relapsed or refractory multiple myeloma (RRMM). We found that optimization beyond potency of degradation, including degradation efficiency and kinetics, could provide efficacy in a lenalidomide-resistant setting. Guided by both phenotypic and protein degradation data, we describe a series of CELMoDs for the treatment of RRMM, culminating in the discovery of CC-92480, a novel protein degrader and the first CELMoD to enter clinical development that was specifically designed for efficient and rapid protein degradation kinetics.

METHODS AND COMPOSITIONS USING 4-AMINO-2-(3-METHYL-2,6-DIOXOPIPERIDIN-3-YL)-ISOINDOLE-1-3-DIONE

This invention relates to racemic and stereomerically pure 4-amino-2-(3-methyl- 2,6-dioxopiperidin-3-yl)-isoindole-1,3-dione, and prodrugs, salts and solvates thereof. Synthesis, methods of use, and pharmaceutical compositions of racemic and stereomerical

Amino-substituted thalidomide analogs: Potent inhibitors of TNF-α production

Thalidomide, (1), is a known inhibitor of TNF-α release in LPS stimulated human PBMC. Herein we describe the TNF-α inhibitory activity of amino substituted analogs of thalidomide (1) and its isoindolin-1-one analog, EM-12 (2). The 4-amino substituted analogs were found to be potent inhibitors of TNF-α release in LPS stimulated human PBMC.