73841-32-4Relevant articles and documents
Synthesis and biological evaluation of unnatural derivatives of narciclasine: 7-aza-nornarciclasine and its N-oxide
Vshyvenko, Sergey,Reisenauer, Mary Rose,Rogelj, Snezna,Hudlicky, Tomas
, p. 4236 - 4238 (2014)
Several unnatural derivatives of narciclasine were prepared in which the C-7 carbon was replaced with nitrogen. The 7-aza derivative and its N-oxide were prepared by the coupling of iodopicolinic acid with a conduramine unit derived chemoenzymatically from bromobenzene. Intramolecular Heck reaction was used to construct the isocarbostyryl ring system. The compounds were submitted to biological screening against cancer cell lines. Full experimental and spectra data are provided for all new compounds.
Piperazine Heteroaryl Derivatives as Gpr38 Agonists
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Page/Page column 13, (2009/01/24)
The invention provides compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Z, X and B are as defined in the specification. The compounds are partial or full agonists at the GPR38 receptor. Pharmaceutical compositions comprising the compounds, methods of preparing the compounds, uses of the compounds and methods involving the compounds are also provided.
ADAMANTYL DERIVATES AS P2X7 RECEPTOR ANTAGONISTS
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Page/Page column 120-121, (2010/10/20)
The invention provides compounds of formula (I) pharmaceutically acceptable salt or solvate thereof, in which R1, A1, m and A are as defined in the specification; a process for their preparation; pharmaceutical compositions containin