73910-85-7

Basic information

• Product Name: 4H-1-Benzopyran-4-one, 3-bromo-2-(4-methoxyphenyl)-
• CAS NO: 73910-85-7
• Molecular Formula: C16H11BrO3
• Molecular Weight: 331.166
• Mol File: 73910-85-7.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-4-one, 3-bromo-2-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-4-one, 3-bromo-2-(4-methoxyphenyl)-(73910-85-7)
• EPA Substance Registry System: 4H-1-Benzopyran-4-one, 3-bromo-2-(4-methoxyphenyl)-(73910-85-7)

Safety Data

• Hazardous Substances Data: 73910-85-7(Hazardous Substances Data)

Upstream product

• 5445-86-3 2'-(4-methoxybenzoyloxy)acetophenone 
• 135276-56-1 C₁₆H₁₄O₄ 
• 4143-74-2 4'-methoxyflavone 
• 4143-72-0 1-(2-hydroxy-phenyl)-3-(4-methoxy-phenyl)-propane-1,3-dione 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 88187-04-6 3-bromo-2,4'-dimethoxyflavan-4-one 
• 3034-08-0 2-(4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-one 
• 39729-17-4 2'-hydroxy-4-methoxychalcone dibromide 
• 133131-57-4 3,3-dibromo-2-(4-methoxy-phenyl)-chroman-4-one 

Downstream Products

• 1373355-47-5 C₂₄H₁₈O₃ 
• 4143-74-2 4'-methoxyflavone 
• 130378-66-4 2-(4-methoxyphenyl)-3-phenyl-4H-1-benzopyran-4-one 
• 101875-57-4 (3-acetoxy-benzofuran-2-yl)-(3-bromo-4-methoxy-phenyl)-ketone 
• 101737-15-9 (3-acetoxy-benzofuran-2-yl)-(4-methoxy-phenyl)-ketone 
• 101279-47-4 (3-bromo-4-methoxy-phenyl)-(3-hydroxy-benzofuran-2-yl)-ketone 
• 131866-10-9 3-bromo-2-(3-bromo-4-methoxy-phenyl)-chromen-4-one 
• 876505-29-2 2-(4-methoxybenzoyl)benzofuran-3-ol 

Relevant articles and documents

One-pot synthesis of 3-haloflavones from flavones using Oxone and potassium halide as a halogenation reagent

A two-step, one-pot method has been developed for the synthesis of 3-haloflavones from the corresponding flavones. The method uses Oxone and potassium halide to produce the active molecular halogen in situ. The solvent (methanol) then participates in the reaction to afford the 2-methoxy-3-haloflavanone derivative. After adding sodium hydroxide, the corresponding 3-haloflavone product is obtained in good to excellent yields. This method provides a convenient synthesis of 3-chloro, 3-bromo and 3-iodo flavones from the same flavone starting material.

A new synthesis of 5-arylbenzo[c]xanthones from photoinduced electrocyclisation and oxidation of (E)-3-styrylflavones

A new synthetic route to 5-arylbenzo[c]xanthones is -established. This was accomplished by use the Heck reaction of 3-bromoflavones with styrene derivatives, leading to (E)-3-styrylflavones with total diastereoselectivity. This transformation was greatly improved under microwave irradiation. The one-pot, photoinduced electrocyclisation of (E)-3-styrylflavones and further in situ oxidation of the cycloadduct leads to 5-arylbenzo[c]xan-thones. Georg Thieme Verlag Stuttgart · New York.

Synthesis and anti-tubulin evaluation of chromone-based analogues of combretastatins

Twenty new hybrid compounds with both combretastatin and flavone moieties were synthesized. These derivatives are classified according to the position of the trimethoxyphenyl ring at C-2 or C-3 of the chromone and presence or absence of a carbonyl as a linker between C-3 and the aryl ring. Most of these compounds were prepared from hesperidin or naringin, two natural and abundant Citrus flavonoids. Seven of these combretastatin analogues revealed anti-tubulin activity but in a medium range.