73932-64-6

Basic information

• Product Name: 1-(biphenyl-4-yl)-2-bromopropan-1-one
• CAS NO: 73932-64-6
• Molecular Formula: C₁₅H₁₃BrO
• Molecular Weight: 289.1671
• Mol File: 73932-64-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 376.5°C at 760 mmHg
• Flash Point: 57.2°C
• Density: 1.336g/cm³
• Vapor Pressure: 7.22E-06mmHg at 25°C
• Refractive Index: 1.591
• CAS DataBase Reference: 1-(biphenyl-4-yl)-2-bromopropan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(biphenyl-4-yl)-2-bromopropan-1-one(73932-64-6)
• EPA Substance Registry System: 1-(biphenyl-4-yl)-2-bromopropan-1-one(73932-64-6)

Safety Data

• Hazardous Substances Data: 73932-64-6(Hazardous Substances Data)

Usage

Type of compound

Ketone derivative

Contains

Bromine atom and a biphenyl group

Usage

Intermediate in the synthesis of various pharmaceuticals and organic compounds

Application

Research and development processes due to unique chemical properties

Potential applications

Production of agrochemicals and other industrial chemicals

Importance

Key component in chemical and pharmaceutical industries due to its properties and applications

Upstream product

• 37940-57-1 1-biphenyl-4-yl-propan-1-one 
• 92-52-4 biphenyl 
• 79-03-8 propionyl chloride 
• 7148-74-5 2-Bromopropionyl chloride 

Downstream Products

• 92-92-2 biphenyl-4-carboxylic acid 
• 109934-36-3 1-biphenyl-4-yl-2-morpholin-4-yl-propan-1-one 
• 77243-18-6 1,3-Bis-(2-biphenyl-4-yl-1-methyl-2-oxo-ethyl)-3H-imidazol-1-ium; bromide 
• 73931-89-2 1-Biphenyl-4-yl-2-imidazol-1-yl-propan-1-one 
• 91306-37-5 2-biphenyl-4-yl-2-(1-bromoethyl)-1,3-dioxolane 
• 4303-85-9 2-Biphenyl-4-yl-2-hydroxy-3,4,4-trimethyl-morpholin-4-ium; bromide 
• 91306-42-2 2-Biphenyl-4-yl-2-(1-phenylselanyl-ethyl)-[1,3]dioxolane 
• 108791-74-8 2-biphenyl-4-yl-2-vinyl-1,3-dioxolane 
• 99502-88-2 2-biphenyl-4-yl-2-(1-phenyltelluro)ethyl-1,3-dioxolane 

Relevant articles and documents

Application of Oxidative Aryl Migration in Organo-selenium and -tellurium Compounds to the Synthesis of 2-Arylpropanoic Acids

The ethylene acetals of aryl α-phenylseleno- and α-phenyltelluro-ethyl ketones i, Ph, Br) and 5-bromo-6-methoxy-2-naphthyl> have been prepared in 12-83percent yields by treating the corresponding α-bromo compounds with diphenyl diselenide-sodium or diphenyl ditelluride-sodium, respectively, in tetrahydrofuran-dimethylformamide under reflux for 6-10 h, during which the bromine is substituted by the PhSe or PhTe group.This substitution is not observed when the (PhM)2-NaBH4-EtOH (M=Se, Te) system which is known as a source of PhM- anion is used.Oxidation of the acetals thus formed with an excess of meta-chloroperbenzoic acid at 20-25 deg C for 1 h affords hydroxy-ethyl 2-arylpropanoates in 56-86percent yields via aryl group migration which are hydrolysed to 2-arylpropanoic acids, some of which are pharmaceutically important compounds.Overall isolated yields of 2-arylpropanoic acids are around 30-42percent based on the starting propiophenones over 5 steps.

NOVEL PHOTOREDUCTIVE ALKYLATION OF METHYL 4-PHENYLBENZOATE WITH ALIPHATIC TERTIARY AMINES

A photoinduced electron-transfer reaction of methyl 4-phenylbenzoate with triethylamine leads to an aminoketone (4), and a photoreductive ethylation product (2) which results from the Norrish Type II reaction of the aminoketone.