73963-62-9 Usage
Description
6-[4-(1-CYCLOHEXYL-1H-TETRAZOL-5-YL) BUTOXY]-2(1H)-QUINOLINONE is a complex organic compound with a unique molecular structure. It is characterized by its off-white to beige solid appearance and is known to be a metabolite of Cilostazol, a pharmaceutical drug used for various therapeutic purposes.
Uses
Used in Pharmaceutical Applications:
6-[4-(1-CYCLOHEXYL-1H-TETRAZOL-5-YL) BUTOXY]-2(1H)-QUINOLINONE is used as an active metabolite for enhancing the therapeutic effects of Cilostazol. As a metabolite, it contributes to the overall pharmacological action of the parent drug, potentially improving its efficacy and safety profile in treating various medical conditions.
Used in Research and Development:
In the field of pharmaceutical research and development, 6-[4-(1-CYCLOHEXYL-1H-TETRAZOL-5-YL) BUTOXY]-2(1H)-QUINOLINONE serves as a valuable compound for studying the metabolic pathways of Cilostazol and understanding its pharmacological properties. This knowledge can be applied to the design and development of new drugs with improved efficacy and reduced side effects.
Used in Quality Control and Analysis:
6-[4-(1-CYCLOHEXYL-1H-TETRAZOL-5-YL) BUTOXY]-2(1H)-QUINOLINONE is also utilized in the quality control and analysis of Cilostazol-containing pharmaceutical products. Its presence can be detected and quantified to ensure the purity, potency, and consistency of the drug, contributing to patient safety and compliance with regulatory standards.
Check Digit Verification of cas no
The CAS Registry Mumber 73963-62-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,9,6 and 3 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 73963-62:
(7*7)+(6*3)+(5*9)+(4*6)+(3*3)+(2*6)+(1*2)=159
159 % 10 = 9
So 73963-62-9 is a valid CAS Registry Number.
InChI:InChI=1/C20H25N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h9-12,14,16H,1-8,13H2,(H,21,26)
73963-62-9Relevant articles and documents
Synthesis of related substances of cilostazol
Zheng, Jin,Liu, Zheng,Dai, Yiru,Zhao, Qingjie,Shen, Jingshan
experimental part, p. 189 - 195 (2009/05/07)
The impurities in API of cilostazol were detected by LC/MS during the process development. The structures of two impurities 6 and 7 and the related formation mechanisms were proposed. Synthesis of 6 and 7 was conducted for confirmation of the speculated structures.
Studies on 2-oxoquinoline derivatives as blood platelet aggregation inhibitors. II. 6-[3-(1-Cyclohexyl-5-tetrazolyl)propoxy]-1,2-dihydro-2-oxoquinoline and related compounds
Nishi,Tabusa,Tanaka,Shimizu,Kanbe,Kimura,Nakagawa
, p. 1151 - 1157 (2007/10/02)
A series of ω-(1-substituted-5-tetrazolylalkoxy)-2-oxoquinolines was synthesized and tested for inhibitory activity towards collagen- and adenosine diphosphate (ADP)-induced aggregation of rabbit blood platelets in vitro. These compounds were prepared by the reaction of 1-substituted-5-(ω-chloroalkyl)-tetrazoles and hydroxy-2-oxoquinolines in the presence of a base. Among them, 6-[3-(1-cyclohexyl-5-tetrazolyl)propoxy]-1,2-dihydro-2-oxoquinoline (IVb) was found to have the most potent inhibitory activity. The structure-activity relationships are discussed.
