74037-41-5Relevant articles and documents
Copper-catalyzed trifluoromethylation of N,N-dialkylhydrazones
Pair, Etienne,Monteiro, Nuno,Bouyssi, Didier,Baudoin, Olivier
supporting information, p. 5346 - 5349 (2013/06/05)
Mild and practical: Trifluoromethylation of (hetero)aromatic aldehyde N,N-dialkylhydrazones was achieved at room temperature by using Togni's trifluoromethylation reagent under CuCl catalysis (see scheme). This simple reaction is believed to occur by a CF3-radical-transfer mechanism and yields useful trifluoromethylated building blocks. Copyright
Conversion of Aldehydes into Nitriles via Oxidation of Their Dimethylhydrazones
Said, Samy Bayomy,Skarzewski, Jacek,Mlochowski, Jacek
, p. 223 - 224 (2007/10/02)
The 3-chloroperoxybenzoic acid oxidation of dimethylhydrazones of aromatic aldehydes gives the corresponding nitriles in good yields.Two further examples of the same oxidative transformation of cinnamaldehyde and of hexanal are also given.Except for hexanal hydrazone, all other aldehyde hydrazones can also be efficiently converted into nitriles by treatment with methanolic 30percent hydrogen peroxide in the presence of catalytic amounts of selenium dioxide or, preferentially, 2-nitrobenzeneseleninic acid.
