74115-12-1 Usage
Description
5-Chloro-3-pyridinol, also known as 5-Chloro-3-hydroxypyridine, is an organic compound with the chemical formula C5H4ClNO. It is an orange-brown to brown crystalline powder that serves as an important intermediate in the synthesis of various pharmaceuticals and chemical compounds.
Uses
Used in Pharmaceutical Industry:
5-Chloro-3-pyridinol is used as a key intermediate in the synthesis of 4-(5-chloropyridin-3-yloxy)isoquinoline, which is a compound with potential applications in the development of new drugs.
Used in Chemical Synthesis:
5-Chloro-3-pyridinol is utilized in the preparation of hydroxybiphenyls through Suzuki-Miyaura cross-coupling reactions with 3-pyridylboronic acid in the presence of a Pd catalyst. This reaction is significant for the creation of various chemical compounds with diverse applications.
Check Digit Verification of cas no
The CAS Registry Mumber 74115-12-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,1,1 and 5 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 74115-12:
(7*7)+(6*4)+(5*1)+(4*1)+(3*5)+(2*1)+(1*2)=101
101 % 10 = 1
So 74115-12-1 is a valid CAS Registry Number.
InChI:InChI=1/C5H4ClNO/c6-4-1-5(8)3-7-2-4/h1-3,8H
74115-12-1Relevant articles and documents
THE REACTIONS OF SOME HALOGENATED PYRIDINES WITH METHOXYDE AND METHANETHIOLATE IONS IN DIMETHYLFORMAMIDE
Testaferri, Lorenzo,Tiecco, Marcello,Tingoli, Marco,Bartoli, Donatella,Massoli, Alberto
, p. 1373 - 1384 (2007/10/02)
The reactions of 2,6- and 2,5-dibromopyridines and of 2,3- and 3,5-dichloropyridines with sodium isopropanethiolate and methanethiolate afforded the products of mono- or of bis-substitution depending on the experimental conditions.The same pyridines reacted with sodium methoxide to give good yields of the mono-substituted products; bis-substitution occurred easily only in the case of the 2,6-dibromo- and of the 3,5-dichloropyridine.The syntheses of some methoxy thiomethoxypyridine, starting from the halogeno methoxypyridines or from the halogeno thiomethoxypyridines are also described.The bis-(alkylthio)pyridines can be fragmented by sodium in HMPA to give the bis(mercapto)pyridines.
