74115-15-4Relevant articles and documents
Hydrogen-bonding patterns in two structural isomers of 3,6-bis(2-chlorophenyl)-1,4-dihydro-1,2,4,5-tetrazine
Zachara, Janusz,Madura, Izabela,Wlostowski, Marek
, p. o57-o59 (2004)
The hydrogen bonding patterns in the structural isomers of 3,6-bis(2-chlorophenyl)-1,4-dihydro-1,2,4,5-tetrazine were discussed. The molecular structure of the isomers consisted of a six-membered central tetrazine ring and two chlorophenyl rings. A contribution from weak interaction to the strong hydrogen-bond was observed. It was found that the main chains of the isomers formed close-packed structure as the zigzag chains were connected together using hydrogen bonds.
Synthesis and antitumor activity of s-tetrazine derivatives
Hu, Wei-Xiao,Rao, Guo-Wu,Sun, Ya-Quan
, p. 1177 - 1181 (2007/10/03)
Fifty-five compounds of s-tetrazine derivative including hexahydro-, 1,6-dihydro, 1,4-dihydro-, 1,2-dihydro- and aromatic s-tetrazine were prepared. Their antitumor activities were evaluated in vitro by MTT method for P-388 cell and SRB method for A-549 cell. The results show that there are 9 compounds which in 10-6 μM have more than 50% inhibition rate to A-549 cancer cell growth, and 7 compounds in 10-6 μM have more than 50% inhibition rate to P-388 cancer cell growth. The IC50 of compound 3q for P-388, Bel-7402, MCF-7 and A-549 are 0.6 μM, 0.6 μM, 0.5 μM and 0. 7 μM, respectively. So s-tetrazine derivative is a kind of compound which possesses potential antitumor activities and is worth to research further.