74205-82-6

Basic information

• Product Name: 1-Hydroxymethyl-1,2,4-triazole
• Synonyms: 1-Hydroxymethyl-1,2,4-triazole;1,2,4-Triazole-1-methanol;1H-1,2,4-Triazole-1-methanol;(1H-1,2,4-Triazol-1-yl)Methanol
• CAS NO: 74205-82-6
• Molecular Formula: C₃H₅N₃O
• Molecular Weight: 99.09
• Mol File: 74205-82-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 70-71℃
• Boiling Point: 290℃
• Flash Point: 129℃
• Appearance: /
• Density: 1.42
• Vapor Pressure: 0.000976mmHg at 25°C
• Refractive Index: 1.632
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 1-Hydroxymethyl-1,2,4-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Hydroxymethyl-1,2,4-triazole(74205-82-6)
• EPA Substance Registry System: 1-Hydroxymethyl-1,2,4-triazole(74205-82-6)

Safety Data

• Hazardous Substances Data: 74205-82-6(Hazardous Substances Data)

Usage

Description

1-Hydroxymethyl-1,2,4-triazole is an organic compound that serves as a key intermediate in the synthesis of various triazole-based compounds. It features a hydroxymethyl group attached to a 1,2,4-triazole ring, which contributes to its unique chemical properties and reactivity.

Uses

Used in Pharmaceutical Industry:
1-Hydroxymethyl-1,2,4-triazole is used as a synthetic intermediate for the development of novel triazole compounds with anti-fungal properties. These compounds are valuable in the creation of new anti-fungal drugs, addressing the need for effective treatments against fungal infections.
Used in Chemical Synthesis:
1-Hydroxymethyl-1,2,4-triazole is utilized as a versatile building block in the synthesis of a wide range of chemical compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its reactivity and functional groups make it a valuable component in the design and synthesis of new molecules with potential applications in various industries.

InChI:InChI=1/C3H5N3O/c7-3-6-2-4-1-5-6/h1-2,7H,3H2

Upstream product

• 288-88-0 1,2,4-Triazole 
• 50-00-0 formaldehyd 

Downstream Products

• 288-88-0 1,2,4-Triazole 
• 84387-62-2 1-chloromethyl-1H-1,2,4-triazole 
• 101-77-9 4,4'-diamino diphenyl methane 
• 119192-10-8 4-(1H-1,2,4-triazol-1-ylmethyl)aniline 
• 843-29-8 N,N’-(4,4’-methylenebis(4,1-phenylene))diacetamide 
• 1807-55-2 4,4'-methylenebis(N-methylaniline) 
• 174264-64-3 4-bromo-2-(1H-1,2,4-triazol-1-ylmethyl)phenol 

Relevant articles and documents

Crystal structure and thermal expansion of N,N,N′,N′-tetrakis-[(1H,2,4-triazol-1-yl)methyl]-ethane-1,2-diamine

The crystal structure of N,N,N′,N′-tetrakis-[(1H,2,4-triazol-1-yl)methyl]-ethane-1,2-diamine has been fully determined at six different temperatures by X-ray single-crystal diffraction, and the thermal expansion has been determined from 100 K to ambient temperature. The expansion is anisotropic, and it is negative in one direction of the unit cell. The supramolecular structure formed by weak hydrogen bonds of the type C-H···N resembles a trellis analogous to that observed in other organic systems with strong hydrogen bonds.

Hydrogen Bond Directed Photocatalytic Hydrodefluorination and Methods of Use Thereof

Methods of synthesizing compounds comprising fluorinated aryl groups are disclosed, wherein said methods utilize hydrogen bond directed photocatalytic hydrodefluorination.

Synthesis of thermoregulated phase-separable triazolium ionic liquids catalysts and application for Stetter reaction

A series of polyether-substituted triazolium ionic liquids catalysts have been first synthesized for resolving the problem of separation and reuse of Stetter catalysts. The catalysts possess the properties of critical solution temperature (CST) and inverse temperature-dependent solubility in toluene/heptane solvents. Based on these properties, the catalysts can achieve the catalytic process named as thermoregulated phase-separable catalysis (TPSC) with the characteristic of homogeneous reaction at higher temperature and phase-separation at lower temperature. The novel TPSC system has been successfully applied for Stetter reaction of furfural or butanal with ethyl acrylate. The experimental results have showed that the novel catalysts exhibit excellent TPSC with high recycling efficiency.