74230-08-3

Basic information

• Product Name: 4-hydroxy-2-nitrobenzoic acid
• Synonyms: 4-hydroxy-2-nitrobenzoic acid;BENZOIC ACID, 4-HYDROXY-2-NITRO-
• CAS NO: 74230-08-3
• Molecular Formula: C₇H₅NO₅
• Molecular Weight: 183.1183
• Mol File: 74230-08-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 230 ºC (DEC.)
• Boiling Point: 414 °C at 760 mmHg
• Flash Point: 190.8 °C
• Appearance: /
• Density: 1.631
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.55±0.25(Predicted)
• CAS DataBase Reference: 4-hydroxy-2-nitrobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-2-nitrobenzoic acid(74230-08-3)
• EPA Substance Registry System: 4-hydroxy-2-nitrobenzoic acid(74230-08-3)

Safety Data

• Hazardous Substances Data: 74230-08-3(Hazardous Substances Data)

Usage

General Description

4-hydroxy-2-nitrobenzoic acid, also known as 2-nitro-4-hydroxybenzoic acid, is a compound with the molecular formula C7H5NO5. It is a derivative of benzoic acid, containing a hydroxyl group and a nitro group at the 4 and 2 positions, respectively. 4-hydroxy-2-nitrobenzoic acid is commonly used as a building block in the synthesis of pharmaceuticals and dyes. It also has potential applications in the field of organic chemistry, particularly in the development of new synthetic methods and strategies. Additionally, 4-hydroxy-2-nitrobenzoic acid has been studied for its potential antioxidant and antimicrobial properties, making it a subject of interest in the fields of medicine and food science.

Upstream product

• 610-36-6 4-amino-2-nitrobenzoic acid 
• 244765-00-2 N-Boc-5-hydroxyanthranilic acid 
• 33844-21-2 2-nitro-4-methoxybenzoic acid 
• 619-57-8 p-hydroxybenzamide 

Downstream Products

• 178758-50-4 methyl 4-hydroxy-2-nitrobenzoate 
• 104356-27-6 ethyl 4-hydroxy-2-nitrobenzoate 
• 38160-63-3 4-hydroxyanthranilic acid 
• 401568-70-5 methyl 2-amino-4-hydroxybenzoate 
• 19013-10-6 ethyl 4-hydroxy-3-nitrobenzoate 

Relevant articles and documents

Application of piperazine structure containing compound to preparation of LSD1 (Lysine Specific Demethylase 1) inhibitor

The invention discloses application of a piperazine structure containing compound to the preparation of a histone lysine specific demethylase (LSD1) inhibitor. The structural general formula of the compound is as shown in the following descriptions (wherein, A is hydrogen, carbonyl or thiocarbonyl) or a configurational isomer and a pharmaceutical salt thereof, or is as shown in the following descriptions or a pharmaceutical salt thereof. The compound has an obvious inhibition effect on the LSD1, can be prepared into the LSD1 inhibitor, and is used for preventing and treating a disease related to the activity of the histone LSD1.

Amyl nitrite-mediated conversion of aromatic and heteroaromatic primary amides to carboxylic acids

A series of aromatic and heteroaromatic primary amides were converted directly to carboxylic acids by heating with amyl nitrite in acetic acid. Most conversions proceeded to give reasonable to excellent yields on a range of substrates containing various functional groups. This reagent system is thus applicable for the direct hydrolysis of a range of different primary carboxamides. The reaction with a phenolic aromatic substrate afforded two alternative nitration products as major outcomes, evidencing alternative reaction pathways resulting from the free phenolic OH.

Substituted aryloximes

The present invention relates to substituted aryl oximes and methods of using them.