74266-66-3

Basic information

• Product Name: 4-BROMO-2-FLUORO-6-NITROANISOLE
• Synonyms: TIMTEC-BB SBB005948;4-BROMO-2-FLUORO-6-NITROANISOLE;4-Bromo-2-fluoro-6-nitro-1-methoxybenzene;4-Bromo-2-fluoro-6-nitroanisol;4-Bromo-2-fluoro-6-nitrophenyl methyl ether, 5-Bromo-1-fluoro-2-methoxy-3-nitrobenzene;5-Bromo-1-fluoro-2-methoxy-3-nitro-benzene
• CAS NO: 74266-66-3
• Molecular Formula: C₇H₅BrFNO₃
• Molecular Weight: 250.02
• EINECS: 1533716-785-6
• Product Categories: Nitro Compounds;Nitrogen Compounds;Organic Building Blocks
• Mol File: 74266-66-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 58-60 °C(lit.)
• Boiling Point: 309.1 °C at 760 mmHg
• Flash Point: 140.7 °C
• Appearance: /
• Density: 1.716 g/cm³
• Vapor Pressure: 0.00119mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-BROMO-2-FLUORO-6-NITROANISOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-FLUORO-6-NITROANISOLE(74266-66-3)
• EPA Substance Registry System: 4-BROMO-2-FLUORO-6-NITROANISOLE(74266-66-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 74266-66-3(Hazardous Substances Data)

Usage

General Description

4-Bromo-2-fluoro-6-nitroanisole is a chemical compound that belongs to the class of anisoles, which are aromatic compounds containing a methoxy group attached to a benzene ring. It is characterized by the presence of a bromine atom, a fluorine atom, and a nitro group on the benzene ring. 4-BROMO-2-FLUORO-6-NITROANISOLE has potential applications in the pharmaceutical and agrochemical industries, including its use as an intermediate in the synthesis of various pharmaceuticals and agrochemical products. It is important to handle this chemical with care and to follow proper safety protocols due to its potential hazards.

InChI:InChI=1/C7H5BrFNO3/c1-13-7-5(9)2-4(8)3-6(7)10(11)12/h2-3H,1H3

Upstream product

• 2105-94-4 4-bromo-2-fluorophenol 
• 367-12-4 2-fluorophenol 
• 403-19-0 2-fluoro-4-nitrophenol 
• 399-96-2 4-amino-2-fluorophenol 

Downstream Products

• 437-83-2 3-fluoro-2-methoxyaniline 
• 394-50-3 3-fluorosalicylaldehyde 
• 74266-68-5 fluoro-3 methoxy-2 benzaldehhyde 
• 239122-51-1 5-bromo-3-fluoro-2-methoxyaniline 
• 708-04-3 2-fluoro-4-methyl-6-nitroanisole 

Relevant articles and documents

Etude des complexes du cobalt (II) transporteurs d'oxygene: Nouvelle synthese du fluoro-3 hydroxy-2 benzaldehyde

Synthetic chelates of cobalt (II) derived from Schiff bases have remarkable behavior of reversibly absorbing and releasing molecular oxygene.Among these, bis (3-fluorosalicylaldehydeethylenediimide) Co (II) (fluomine: Formula A, X=F) is most interesting in allowing to isolate pure oxygen from air, because it absorbs with extreme rapidity 4.43percent of its weight of oxygen.Fluomine is easily prepared from 3-fluorosalicylaldehyde (3FSA), ethylenediamine and cobalt (II) chloride; but substances such as 3-substituted salicylaldehydes have proven to be extremely difficult to prepare in other than small laboratory quantities from the corresponding ortho-substituted phenol.Many author have prepared 3-fluorosalicylaldehyde, as described in patents, but often these syntheses are very long and the yields are generally less than 20percent.We now describe a new synthesis from o-fluorophenol.Nitration of o-fluorophenol with liquid nitrogen dioxide is convenient: - on the one hand, ortho-substitution to the hydroxyl group, is easy, -on the other hand, the para substituted by-product, is reinserted in the course of the synthesis, so that it is possible to minimize loss of the starting phenol, an expensive product. o-Fluorophenol 1 in solution in pentane, at about 0 deg C, is treated with liquid nitrogen dioxide (slight excess).The reaction is rapid and leads to 2-fluoro 6-nitrophenol 2 which remains in solution, and 2-fluoro 4-nitrophenol 7 which cristallizes rapidly (approximatively 50percent of each one). 2-Fluoro 6-nitrophenol 2 is converted into the anisole 3, the NO2 group of which is catalytically reduced by hydrogen into 3-fluoro 2-methoxy-aminobenzene 4.This amine 4 is diazotized, and treated with formaldoxime to lead to 3-fluoro 2-methoxybenzaldehyde 5 (Eb12 = 82 deg C). 3FSA is finally obtained by heating under reflux anisole 5 and a solution of hydrobromic acid (48percent). 2-Fluoro 4-nitrophenol 7 is converted in five steps into 3-fluoro 2-methoxyaminobenzene 4 by the same reactions as these used for its isomer.Finally the total yield of amine 4 from o-fluorophenol is 73percent, and 3FSA is obtained in 25percent yield.No primary amines are required during the isolation, so that no possible contamination of the final product is possible and therefore the fluomine prepared therefrom is not contaminated and deactivated.