74291-57-9

Basic information

• Product Name: 1,2,3,4-TETRAHYDRO-2-(TRIFLUOROACETYL)ISOQUINOLINE-7-SULFONYL CHLORIDE
• Synonyms: 1,2,3,4-TETRAHYDRO-2-(TRIFLUOROACETYL)ISOQUINOLINE-7-SULFONYL CHLORIDE;1,2,3,4-TETRAHYDRO-2-(TRIFLUOROACETYL)ISOQUINOLINE-7-SULPHONYL CHLORIDE;2-(trifluoroacetyl)-1,2,3,4-tetrahydro-7-isoquinolinesulfonyl chloride(SALTDATA: FREE);1,2,3,4-Tetrahydro-2-(2,2,2-trifluoroacetyl)-;2-(2,2,2-Trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride;2-Trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride, 99%;2-(Trifluoroacetyl)-1,2,3,4-tetrahydro-7-isoquinolinesulfonyl chloride;Tetrahydro-2-(trifluoroacetyl)isoquinoline-7-sulfonyl chloride
• CAS NO: 74291-57-9
• Molecular Formula: C₁₁H₉ClF₃NO₃S
• Molecular Weight: 327.71
• EINECS: -0
• Product Categories: Aromatics;Heterocycles;Inhibitors;Sulfur & Selenium Compounds
• Mol File: 74291-57-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 102-104°C
• Boiling Point: 465.6°C at 760 mmHg
• Flash Point: 235.4°C
• Appearance: /
• Density: 1.548g/cm³
• Vapor Pressure: 7.62E-09mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.07±0.20(Predicted)
• Sensitive: Moisture Sensitive
• BRN: 5603124
• CAS DataBase Reference: 1,2,3,4-TETRAHYDRO-2-(TRIFLUOROACETYL)ISOQUINOLINE-7-SULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-TETRAHYDRO-2-(TRIFLUOROACETYL)ISOQUINOLINE-7-SULFONYL CHLORIDE(74291-57-9)
• EPA Substance Registry System: 1,2,3,4-TETRAHYDRO-2-(TRIFLUOROACETYL)ISOQUINOLINE-7-SULFONYL CHLORIDE(74291-57-9)

Safety Data

• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: 3261
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 74291-57-9(Hazardous Substances Data)

Usage

Uses

1,2,3,4-Tetrahydro-2-(trifluoroacetyl)isoquinoline-7-sulfonyl Chloride is an intermediate for the preparation of 5-heteroaryl thiazoles and their use as phosphoinositide 3-kinase (PI3K) inhibitors.

InChI:InChI=1/C11H9ClF3NO3S/c12-20(18,19)9-2-1-7-3-4-16(6-8(7)5-9)10(17)11(13,14)15/h1-2,5H,3-4,6H2

Upstream product

• 55649-51-9 2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 181514-35-2 1-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-2,2,2-trifluoroethan-1-one 

Downstream Products

• 74291-58-0 2-(2,2,2-Trifluoro-acetyl)-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid (2,3-dichloro-phenyl)-amide 
• 936847-38-0 N-phenethyl-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide 
• 936847-42-6 2-(5-isopropyl-2,3,4-trimethoxybenzoyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonic acid phenethyl-amide 
• 936847-35-7 2-{2,3,4-trimethoxy-5-[methyl-(3-phenylpropyl)sulfamoyl]benzoyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonic acid phenethylamide 
• 760123-89-5 N-phenethyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide 
• 74291-33-1 1,2,3,4-Tetrahydro-isoquinoline-7-sulfonic acid (2,3-dichloro-phenyl)-amide; hydrochloride 
• 184879-73-0 N-(2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline-7-sulphonyl)-3-(1-benzyl-1,2,5,6-tetrahydro-3-pyridyl)-(S)-alanine t-butyl ester 

Relevant articles and documents

ISOQUINOLINE DERIVATIVES AS MGAT2 INHIBITORS

The compounds of Formula I act as MGAT2 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity.

Identification of 2-[2-(4-tert-butylphenyl)ethyl]-N-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide (29) as an orally available MGAT2 inhibitor

MGAT2 (monoacylglycerol acyltransferase 2) is expected to be an attractive target for the drug treatment of obesity, diabetes, and other disease. We describe our exploration and structure-activity relationship (SAR) study of 2,3-dihydro-1H-isoindole-5-sul

Antithrombotic amidinophenylalanine and amidinopyridylalanine derivatives

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