743357-99-5 Usage
General Description
2-Amino-2'-chloroacetophenone, also known as CN or mace, is a chemical compound that is classified as a toxic irritant. It is a derivative of acetophenone and is used in riot control agents and as a tear gas. CN is a yellow crystalline solid with a pungent odor, and it is soluble in organic solvents. When used as a riot control agent, CN causes irritation to the eyes, nose, and throat, leading to tears, sneezing, coughing, and a burning sensation. Prolonged exposure to CN can cause skin irritation and damage. Due to its toxic and irritating properties, CN is regulated and restricted in many countries, and its use is mainly limited to law enforcement and military applications.
Check Digit Verification of cas no
The CAS Registry Mumber 743357-99-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,4,3,3,5 and 7 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 743357-99:
(8*7)+(7*4)+(6*3)+(5*3)+(4*5)+(3*7)+(2*9)+(1*9)=185
185 % 10 = 5
So 743357-99-5 is a valid CAS Registry Number.
743357-99-5Relevant articles and documents
Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid
Pfefferkorn, Jeffrey A.,Greene, Meredith L.,Nugent, Richard A.,Gross, Rebecca J.,Mitchell, Mark A.,Finzel, Barry C.,Harris, Melissa S.,Wells, Peter A.,Shelly, John A.,Anstadt, Robert A.,Kilkuskie, Robert E.,Kopta, Laurice A.,Schwende, Francis J.
, p. 2481 - 2486 (2007/10/03)
A novel series of nonnucleoside HCV NS5B polymerase inhibitors were prepared from (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid, a high throughput screening lead. SAR studies combined with structure based drug design focusing on the southern heterobiaryl region of the template led to the synthesis of several potent and orally bioavailable lead compounds. X-ray crystallography studies were also performed to understand the interaction of these inhibitors with HCV NS5B polymerase.