74356-00-6 Usage
Description
Disodium (7R)-7-[[4-(carbamoyl-carboxylato-methylidene)-1,3-dithietane-2-carbonyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate is a complex organic compound with a unique chemical structure. It is characterized by the presence of a 1,3-dithietane-2-carbonyl moiety, a carbamoyl-carboxylato-methylidene group, and a 1-methyltetrazol-5-ylsulfanylmethyl substituent. Disodium (7R)-7-[[4-(carbamoyl-carboxylato-methylidene)-1,3-dithietane-2-carbonyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate is a disodium salt, indicating that it has two sodium ions associated with it. Its structure and properties suggest potential applications in various fields, such as pharmaceuticals or materials science.
Uses
Used in Pharmaceutical Industry:
Disodium (7R)-7-[[4-(carbamoyl-carboxylato-methylidene)-1,3-dithietane-2-carbonyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate is used as a pharmaceutical compound for its potential therapeutic effects. The complex structure and functional groups present in the molecule may contribute to its interaction with biological targets, such as enzymes or receptors, leading to potential applications in treating various diseases or conditions.
Used in Materials Science:
In the field of materials science, Disodium (7R)-7-[[4-(carbamoyl-carboxylato-methylidene)-1,3-dithietane-2-carbonyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate may be utilized for the development of novel materials with specific properties. The unique structure and functional groups of the compound could be exploited to create materials with tailored characteristics, such as improved stability, reactivity, or selectivity, for use in various applications.
Originator
Yamanouchi (Japan)
Clinical Use
Cefotetan (Cefotan) is a third-generation cephalosporin thatis structurally similar to cefoxitin. Like cefoxitin, cefotetanis resistant to destruction by β-lactamases. It is also a competitiveinhibitor of many β-lactamases and causes transient inactivation of some of these enzymes. Cefotetan is reportedto synergize with β-lactamase–sensitive β-lactams but, unlikecefoxitin, does not appear to cause antagonism.The antibacterial spectrum of cefotetan closely resemblesthat of cefoxitin. It is, however, generally more activeagainst S. aureus, and members of the Enterobacteriaceaefamily sensitive to both agents. It also exhibits excellentpotency against H. influenzae and N. gonorrhoeae, includingβ-lactamase–producing strains. Cefotetan is slightly lessactive than cefoxitin against B. fragilis and other anaerobes.Enterobacter spp. are generally resistant to cefotetan, andthe drug is without effect against Pseudomonas spp.Cefotetan has a relatively long half-life of about 3.5hours. It is administered on a twice-daily dosing schedule. Itis excreted largely unchanged in the urine. Aqueoussolutions for parenteral administration maintain potency for24 hours at 25°C. Refrigerated solutions are stable for 4 days.Cefotetan contains the MTT group that has been associatedwith hypoprothrombinemia and alcohol intolerance.Another cephalosporin that lacks these properties should beselected for patients at risk for severe bleeding or alcoholism.
Veterinary Drugs and Treatments
Cefotetan may be a reasonable choice for treating serious infections
caused by susceptible bacteria, including E. coli or anaerobes.
It appears to be well tolerated in small animals and may be given
less frequently than cefoxitin.
Check Digit Verification of cas no
The CAS Registry Mumber 74356-00-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,3,5 and 6 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 74356-00:
(7*7)+(6*4)+(5*3)+(4*5)+(3*6)+(2*0)+(1*0)=126
126 % 10 = 6
So 74356-00-6 is a valid CAS Registry Number.
InChI:InChI=1/C17H17N7O8S4.2Na/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28;;/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30);;/q;2*+1/p-2/b12-6-;;/t13?,15?,17-;;/m0../s1
74356-00-6Relevant articles and documents
Preparation method of anti-infection cephalosporin drug
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Paragraph 0017; 0046-0049, (2021/05/05)
The invention discloses a preparation method of an anti-infection cephalosporin drug. The method comprises the following steps: reacting 7-MAC(II) with 2-oxoacetic acid hydrate to prepare a compound III, carrying out thioacetalation reaction on the compound III and 2-carbamoyl-3, 3-dimercaptoacrylic acid to prepare a compound IV, and carrying out deprotection and salification to prepare cefotetan disodium (I). The synthetic route is simple, the reaction condition is mild, the generation of impurities is reduced, the total yield and purity of the product are improved, and the method is suitable for industrial production.
