74387-77-2Relevant articles and documents
Novel High Energy Intermediate Analogues with Triazasterol-Related Structures as Inhibitors of Ergosterol Biosynthesis. Part I: Synthesis and Antifungal Activity of N-alkyl-N'-(phenethyl- and cyclohexenylethyl)guanidines and N2-Substituted 2-Imidazolinamines
Goessnitzer, Edith,Malli, Roland,Schuster, Silvia,Favre, Bertrand,Ryder, Neil S.
, p. 535 - 546 (2007/10/03)
A series of N-alkyl-N'-(phenethyl- and cyclohexenylethyl)guanidines and N2- and N2,4-substituted imidazolin-2-amine hydrochlorides with triazasterol-related structures was designed and synthesized as stable analogues to mimic high energy intermediates of ergosterol biosynthesis. The in vivo antifungal susceptibility tests with a standard panel of pathogenic fungi revealed moderate to strong antimycotic effects of the sixteen prepared compounds, in some cases comparable with the activity observed for itraconazole.