74405-46-2 Usage
Description
IBU-DMT-DEOXYGUANOSINE SUCCINIC ACID, also known as 2''-Deoxy-5''-O-DMT-N2-isobutyrylguanosine 3''-O-succinate, is a nucleoside derivative with significant applications in the field of molecular biology and biotechnology. It plays a crucial role in the synthetic preparation of DNA fragments, including the formation of small-molecule/DNA hybrids through amide coupling. Its unique chemical structure allows it to serve as a solid phase support for oligonucleotide synthesis, facilitating the development of novel therapeutic strategies and diagnostic tools.
Uses
Used in Molecular Biology and Biotechnology:
IBU-DMT-DEOXYGUANOSINE SUCCINIC ACID is used as a synthetic building block for the preparation of DNA fragments, particularly in the creation of small-molecule/DNA hybrids via amide coupling. This application is essential for the development of innovative therapeutic approaches and the advancement of molecular biology research.
Used in Oligonucleotide Synthesis:
IBU-DMT-DEOXYGUANOSINE SUCCINIC ACID serves as a solid phase support for oligonucleotide synthesis, enabling the efficient and reliable production of specific DNA sequences. This application is vital for the development of targeted gene therapies, diagnostic tools, and other biotechnological applications that require precise control over DNA sequence synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 74405-46-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,4,0 and 5 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 74405-46:
(7*7)+(6*4)+(5*4)+(4*0)+(3*5)+(2*4)+(1*6)=122
122 % 10 = 2
So 74405-46-2 is a valid CAS Registry Number.
InChI:InChI=1/C39H41N5O10/c1-23(2)36(48)42-38-41-35-34(37(49)43-38)40-22-44(35)31-20-29(54-33(47)19-18-32(45)46)30(53-31)21-52-39(24-8-6-5-7-9-24,25-10-14-27(50-3)15-11-25)26-12-16-28(51-4)17-13-26/h5-17,22-23,29-31H,18-21H2,1-4H3,(H,45,46)(H2,41,42,43,48,49)
74405-46-2Relevant articles and documents
Stereospecific grignard activated coupling of a deoxynucleoside: Methylphosphonate on a polyethylene glycol support
Le Bec, Christine,Wickstrom, Eric
, p. 9525 - 9528 (1994)
Stereospecific synthesis of Rp and Sp methylphosphonate diastereoisomers of d(ApG) was carried out on a polymeric support, polyethylene glycol (PEG), by the Grignard reagent solution route described by Stec. The coupling yield on PEG was higher than that observed in solution, and precipitation of the PEG at each step allowed easy separation of oligomer product from soluble reactants at each step.