74457-86-6 Usage
Description
2-Fluoro-4-methoxyacetophenone is an organic compound characterized by its white to light yellow crystal powder appearance. It is a derivative of acetophenone, featuring a fluorine atom at the 2nd position and a methoxy group at the 4th position of the benzene ring.
Uses
Used in Chemical Synthesis:
2-Fluoro-4-methoxyacetophenone is used as an intermediate in the chemical synthesis industry for the production of various compounds. Its unique structure with a fluorine atom and a methoxy group makes it a valuable building block for creating a range of molecules with different properties and applications.
The specific application reasons for 2-Fluoro-4-methoxyacetophenone in chemical synthesis are not provided in the materials. However, given its structural features, it is likely used to introduce fluorine and methoxy functionalities into other molecules, which can influence the reactivity, stability, and biological activity of the resulting compounds.
Preparation
Obtained by reaction of acetic anhydride with 3-fluoroanisole in the presence of aluminium chloride in carbon disulfide at r.t., then at 30–35° until no more hydrochloric acid is evolved.
Check Digit Verification of cas no
The CAS Registry Mumber 74457-86-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,4,5 and 7 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 74457-86:
(7*7)+(6*4)+(5*4)+(4*5)+(3*7)+(2*8)+(1*6)=156
156 % 10 = 6
So 74457-86-6 is a valid CAS Registry Number.
74457-86-6Relevant articles and documents
Pd-Catalysed direct C(sp2)-H fluorination of aromatic ketones: Concise access to anacetrapib
Wu, Qiuzi,Mao, Yang-Jie,Zhou, Kun,Wang, Shuang,Chen, Lei,Xu, Zhen-Yuan,Lou, Shao-Jie,Xu, Dan-Qian
supporting information, p. 4544 - 4547 (2021/05/17)
The Pd-cataylsed direct ortho-C(sp2)-H fluorination of aromatic ketones has been developed for the first time. The reaction features good regioselectivity and simple operations, constituting an alternative shortcut to access fluorinated ketones. A concise synthesis of anacetrapib has also been achieved by using late-stage C-H fluorination as a key step.
LiClO4-acyl anhydrides complexes as powerful acylating reagents of aromatic compounds in solvent free conditions
Bartoli, Giuseppe,Bosco, Marcella,Marcantoni, Enrico,Massaccesi, Massimo,Rinaldi, Samuele,Sambri, Letizia
, p. 6331 - 6333 (2007/10/03)
The Friedel-Crafts acylation of various activated benzenes is smoothly carried out with acyl anhydrides in the presence of 2 equiv. of LiClO4, as reaction promoter, under solventless conditions.
Method of treating diabetes and related disease states.
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, (2008/06/13)
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