7448-86-4

Basic information

• Product Name: 1-(4-methoxyphenyl)prop-2-en-1-one
• Synonyms: 1-(4-Methoxyphenyl)-2-propen-1-one; 2-propen-1-one, 1-(4-methoxyphenyl)-
• CAS NO: 7448-86-4
• Molecular Formula: C₁₀H₁₀O₂
• Molecular Weight: 162.1852
• Mol File: 7448-86-4.mol
• Article Data: 74

Chemical Properties

• Boiling Point: 266.2°C at 760 mmHg
• Flash Point: 116.2°C
• Density: 1.035g/cm³
• Vapor Pressure: 0.00875mmHg at 25°C
• Refractive Index: 1.516
• CAS DataBase Reference: 1-(4-methoxyphenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxyphenyl)prop-2-en-1-one(7448-86-4)
• EPA Substance Registry System: 1-(4-methoxyphenyl)prop-2-en-1-one(7448-86-4)

Safety Data

• Hazardous Substances Data: 7448-86-4(Hazardous Substances Data)

Usage

Safety Profile

A questionable carcinogen. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating vapors.

Upstream product

• 2125-49-7 3-dimethylamino-1-(4-methoxy-phenyl)-propan-1-one; hydrochloride 
• 100-66-3 methoxybenzene 
• 625-36-5 2-chloropropionyl chloride 
• 51410-44-7 1-(4-methoxylphenyl)-2-propen-1-ol 
• 33994-11-5 α-Bromoethyl p-methoxaphenyl ketone 
• 95605-45-1 [3-(4-methoxy-phenyl)-3-oxo-propyl]-trimethyl-ammonium; bromide 
• 18096-70-3 3-dimethylamino-4'-methoxyacrylophenone 
• 87015-46-1 1-(4-methoxyphenyl)-3-tosylpropan-1-one 
• 87015-44-9 3-((4-chlorophenyl)sulfonyl)-1-(4-methoxyphenyl)propan-1-one 
• 77253-67-9 trifluoroethanol-d₃ 
• 81112-07-4 2-chloro-1-(4'-methoxyphenyl)-propan-1-one 
• 3153-44-4 4-(4-methoxy-phenyl)-4-oxo-butyric acid 
• 201230-82-2 carbon monoxide 
• 7486-35-3 tri-n-butyl(vinyl)tin 

Downstream Products

• 103990-59-6 N,N-bis-[3-(4-methoxy-phenyl)-3-oxo-propyl]-O-methyl-hydroxylamine 
• 121-97-1 4-Methoxypropiophenone 
• 3314-43-0 3-(4-methoxy-phenyl)-1-phenyl-4,5-dihydro-1H-pyrazole 
• 67756-15-4 1-(4-Methoxyphenyl)-1,4-decandion 
• 60755-22-8 1-(4-methoxyphenyl)-4-phenyl-1,4-butanedione 
• 15982-64-6 1,4-bis(4-methoxyphenyl)butane-1,4-dione 
• 2108-54-5 1-(4-methoxyphenyl)pentane-1,4-dione 
• 54605-99-1 (4-methoxyphenyl)(3-methyl-4,5-dihydroioxazol-5-yl)methanone 
• 87015-46-1 1-(4-methoxyphenyl)-3-tosylpropan-1-one 
• 143619-29-8 (S)-2-Cyano-5-(4-methoxy-phenyl)-2-methyl-5-oxo-pentanoic acid isopropyl ester 
• 143619-29-8 (R)-2-Cyano-5-(4-methoxy-phenyl)-2-methyl-5-oxo-pentanoic acid isopropyl ester 
• 87015-44-9 3-((4-chlorophenyl)sulfonyl)-1-(4-methoxyphenyl)propan-1-one 
• 130767-31-6 (E)-3-(2,4-Dimethoxy-pyrimidin-5-yl)-1-(4-methoxy-phenyl)-propenone 
• 14006-70-3 3-indol-3-yl-1-(4-methoxy-phenyl)-propan-1-one 

Relevant articles and documents

Rational modification of Mannich base-type derivatives as novel antichagasic compounds: Synthesis, in vitro and in vivo evaluation

The current chemotherapy against Chagas disease is inadequate and insufficient. A series of ten Mannich base-type derivatives have been synthesized to evaluate their in vitro antichagasic activity. After a preliminary screening, compounds 7 and 9 were sub

Rongalite as C1 Synthon and Sulfone Source: A Practical Sulfonylmethylation Based on the Separate-Embedding Strategy

Rongalite has been used in several challenging synthetic transformations with operationally simple and effective protocols. However, the employment of multiple characteristics of rongalite in synthetic chemistry is comparatively little known. Herein we report a separate-embedding type sulfonylmethylation of sulfoxonium ylides in which rongalite concurrently acted as a sulfone source, C1 synthon, radical initiator, and potential reducing reagent for the first time. Notably, this facile and easy-handling reaction does not require a catalyst or prefunctionalized sulfonylmethylation reagents.

Nickel-Catalyzed C(sp3)-H Functionalization of Benzyl Nitriles: Direct Michael Addition to Terminal Vinyl Ketones

An efficient nickel(0)-catalyzed addition of benzyl nitriles to terminal vinyl ketones via C(sp3)-H functionalization has been developed. The reaction provides a novel and efficient protocol for the synthesis of α-functionalized benzyl nitriles with a wide range of structural diversity under mild reaction conditions while obviating the use of a strong base. The work might be potentially useful toward the development of an enantioselective variant using chiral nitrogen ligands.

Enantioselective Copper-Catalyzed Electrophilic Sulfenylation of Cyclic Imino Esters

Herein we report an enantioselective sulfenylation of cyclic imino esters with the efficient and versatile sulfenylation reagent S-alkyl 4-methylbenzenesulfonothioates. By utilizing the Cu/tBu-Phosferrox catalytic system, we can assemble diverse S-alkyl groups into the cyclic imino esters under mild conditions in good yields and with excellent enantioselectivities. Remarkably, this method demonstrates a high tolerance of diverse functional groups and proves to be applicable in the late-stage functionalization of pharmaceuticals.