74483-52-6

Basic information

• Product Name: BENZENE, 1-FLUORO-2-METHYL-4-(TRIFLUOROMETHYL)-
• Synonyms: BENZENE, 1-FLUORO-2-METHYL-4-(TRIFLUOROMETHYL)-;4-FLUORO-3-METHYLBENZOTRIFLUORIDE
• CAS NO: 74483-52-6
• Molecular Formula: C₈H₆F₄
• Molecular Weight: 178.13
• Mol File: 74483-52-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 127.8°C at 760 mmHg
• Flash Point: 16.2°C
• Appearance: /
• Density: 1.241g/cm³
• Vapor Pressure: 13.3mmHg at 25°C
• Refractive Index: 1.416
• CAS DataBase Reference: BENZENE, 1-FLUORO-2-METHYL-4-(TRIFLUOROMETHYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: BENZENE, 1-FLUORO-2-METHYL-4-(TRIFLUOROMETHYL)-(74483-52-6)
• EPA Substance Registry System: BENZENE, 1-FLUORO-2-METHYL-4-(TRIFLUOROMETHYL)-(74483-52-6)

Safety Data

• Hazardous Substances Data: 74483-52-6(Hazardous Substances Data)

Usage

General Description

BENZENE, 1-FLUORO-2-METHYL-4-(TRIFLUOROMETHYL)- is a chemical compound with the molecular formula C9H6F4. It is a colorless liquid with a strong, sweet odor. BENZENE, 1-FLUORO-2-METHYL-4-(TRIFLUOROMETHYL)- is mainly used as a building block in the production of pharmaceuticals, agrochemicals, and specialty chemicals. It is also used as a solvent in various industrial processes. BENZENE, 1-FLUORO-2-METHYL-4-(TRIFLUOROMETHYL)- is considered to be a hazardous chemical and should be handled with care due to its toxic and flammable nature.

InChI:InChI=1/C8H6F4/c1-5-4-6(8(10,11)12)2-3-7(5)9/h2-4H,1H3

Upstream product

• 352-70-5 m-Fluorotoluene 
• 929000-62-4 1-bromo-2-methyl-4-(trifluoromethyl)benzene 

Relevant articles and documents

Metal-Catalyzed Carbon-Fluorine Bond Formation

One aspect of the invention relates to a metal-catalyzed conversion of aryl halides and sulfonates to the corresponding aryl fluorides. Another aspect of the invention relates to a metal-catalyzed conversion of heteroaryl halides and sulfonates to the corresponding heteroaryl fluorides. Another aspect of the invention relates to a metal-catalyzed conversion of vinyl halides and sulfonates to the corresponding vinyl fluorides. In certain embodiments, simple fluoride sources, such as AgF and CsF, are used. In certain embodiments, the transformations tolerate a wide range of functional groups, allowing for introduction of fluorine atoms into highly functionalized organic molecules.

Process for the preparation of aromatic trifluoromethyl compounds

A process for the preparation of an aromatic trifluoromethyl compound which comprises contacting an aromatic compound of the formula STR1 wherein R1 denotes hydrogen, alkyl, aryl, aralkyl, aryloxy, arylthio, polyhalogenoalkoxy or polyhalogenoalkylthio and the aromatic substituents R1 can in turn be substituted by halogen, alkyl, polyhalogenoalkyl, polyhalogenoalkoxy, polyhalogenoalkylthio, nitro, chlorocarbonyl or chlorosulfonyl, and R2, R3, R4 and R5 are independently hydrogen, halogen or alkyl and two adjacent radicals of the group R1 to R5 can conjointly form a three-membered to five-membered alkylene radical, with carbon tetrachloride and hydrogen fluoride at a temperature in the range of 50° C. to 140° C. Certain new aromatic trifluoromethyl compounds which can prepared by such a process are also disclosed.