745-62-0 Usage
Description
Prostaglandin F1α (PGF1α) is a metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. It is a serum eicosanoid and belongs to the PGF group of prostaglandins, which are known for their five-member ring structure and varying functions. PGF1α is characterized by its role as a priming pheromone for male Atlantic salmon and its ability to induce human respiratory smooth muscle contractions, although it is less potent than PGF2α.
Uses
1. Used in Aquatic Biology:
PROSTAGLANDIN F1ALPHA is used as a priming pheromone for male Atlantic salmon to stimulate their reproductive behavior.
2. Used in Pharmaceutical Research:
PROSTAGLANDIN F1ALPHA is used as a smooth muscle relaxant and a stable metabolite of prostacyclin (PGI2) for studying its effects on human respiratory smooth muscle contractions.
3. Used in Mass Spectrometry and Related Applications:
PROSTAGLANDIN F1ALPHA is used as a quantitative grade standard, specifically prepared for mass spectrometry, to ensure accurate and reproducible results in related applications. The PGF1α MaxSpec standard guarantees identity, purity, stability, and concentration specifications, making it suitable for precise measurements and calibration standards.
Biochem/physiol Actions
PGs mediate vasodilation and vasoconstriction.
Check Digit Verification of cas no
The CAS Registry Mumber 745-62-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,4 and 5 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 745-62:
(5*7)+(4*4)+(3*5)+(2*6)+(1*2)=80
80 % 10 = 0
So 745-62-0 is a valid CAS Registry Number.
InChI:InChI=1/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
745-62-0Relevant articles and documents
Regio- and Stereoselectivity of the Reaction between Cyanocuprates and Cyclopentene Epoxides. Application to the Total Synthesis of Prostaglandins
Marino, Joseph P.,Pradilla, Roberto F. de la,Laborde, Edgardo
, p. 4898 - 4913 (2007/10/02)
A systematic study of the reaction between cyclopentene epoxides and alkyl-, alkenyl-, and arylcyanocuprates is described.Alkylcyanocuprates react with complete regio- and stereoselectivity to provide trans-4-alkylcyclopent-2-enols in excellent yields.Vin
Cyclopentanones. XVII: prostaglandin synthesis involving the lithium liquid ammonia reduction of 3 alkyl 4 hydroxy 2 (1 octynyl) 2 cyclopentenones
De Clercq,De Smet,Legein,et al.
, p. 503 - 522 (2007/10/13)
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Synthetic studies on prostaglandins.
Holden,Hwang,Williams,Weinstock,Harman,Weisbach
, p. 1569 - 1574 (2007/10/14)
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