745048-63-9

Basic information

• Product Name: 5-amino-2-bromo-4-methylbenzoic acid
• Synonyms: 5-amino-2-bromo-4-methylbenzoic acid;3-Amino-6-bromo-4-methylbenzoic acid
• CAS NO: 745048-63-9
• Molecular Formula: C₈H₈BrNO₂
• Molecular Weight: 230
• EINECS: 1533716-785-6
• Mol File: 745048-63-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 380.2±42.0 °C(Predicted)
• Appearance: /
• Density: 1.682±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.16±0.10(Predicted)
• CAS DataBase Reference: 5-amino-2-bromo-4-methylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-2-bromo-4-methylbenzoic acid(745048-63-9)
• EPA Substance Registry System: 5-amino-2-bromo-4-methylbenzoic acid(745048-63-9)

Safety Data

• Hazardous Substances Data: 745048-63-9(Hazardous Substances Data)

Usage

General Description

5-Amino-2-bromo-4-methylbenzoic acid is an organic compound that belongs to the class of compounds known as benzene and substituted derivatives. As indicated by its name, it consists of an amino group, a bromo substituent, a methyl group, and a carboxylic acid function attached to the benzene ring. 5-Amino-2-bromo-4-methylbenzoic acid is generally used in chemical and pharmaceutical research. It can act as a precursor for the synthesis of various other chemicals. Not much information is available about its toxicity, solubility, or environmental effects. However, standard safety procedures should be followed while handling it due to its potential reactivity as an amine and carboxylic acid.

Upstream product

• 4478-10-8 2-bromo-1-isopropyl-4-methyl-benzene 
• 859816-42-5 1-bromo-2-isopropyl-5-methyl-4-nitro-benzene 
• 2458-12-0 3-amino-p-toluic acid 

Downstream Products

• 474330-54-6 5-amino-2-bromo-4-methylbenzoic acid methyl ester 
• 1061314-02-0 2-bromo-5-chloro-4-methyl-benzoic acid methyl ester 
• 1313513-41-5 methyl 2-bromo-4-(bromomethyl)-5-chlorobenzoate 
• 1313513-42-6 methyl 4-(acetoxymethyl)-2-bromo-5-chlorobenzoate 
• 1313513-39-1 2-bromo-5-chloro-4-(hydroxymethyl)benzoic acid 
• 1313513-45-9 C₁₇H₂₆BrClO₃Si 
• 1313513-46-0 (2-bromo-5-chloro-4-((triisopropylsilyloxy)methyl)phenyl)methanol 
• 1313513-44-8 (4-(allyloxymethyl)-5-bromo-2-chlorobenzyloxy)triisopropylsilane 
• 1313513-47-1 2-(4-(allyloxymethyl)-2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)acetic acid 
• 1313513-48-2 2-(4-(allyloxymethyl)-2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)benzyl)-5-(furan-2-yl)thiazole 
• 1313513-49-3 (2S,3R,4R,5S,6R)-2-(4-chloro-5-((5-(furan-2-yl)thiazol-2-yl)methyl)-2-(hydroxymethyl)phenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol 
• 1313513-53-9 (2S,3R,4R,5S,6R)-2-(2-(allyloxymethyl)-4-chloro-5-((5-(furan-2-yl)thiazol-2-yl)methyl)phenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol 
• 1313513-50-6 (2S,3R,4R,5S,6R)-2-(4-chloro-5-((5-(furan-3-yl)thiazol-2-yl)methyl)-2-(hydroxymethyl)phenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol 
• 1313513-54-0 (2S,3R,4R,5S,6R)-2-(2-(allyloxymethyl)-4-chloro-5-((5-(furan-3-yl)thiazol-2-yl)methyl)phenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol 

Relevant articles and documents

PURINONE COMPOUNDS AND THEIR USE IN TREATING CANCER

The specification generally relates to compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, where R1, A1, A2 and A3 have any of the meanings defined herein. The specification also relates to the use of such compounds and salts thereof to treat or prevent DNA-PK mediated disease, including cancer. The specification further relates to pharmaceutical compositions comprising such compounds and salts; kits comprising such compounds and salts; methods of manufacture of such compounds and salts; intermediates useful in the manufacture of such compounds and salts; and to methods of treating DNA-PK mediated disease, including cancer, using such compounds and salts.

Pyrano[3,2-c]benzopyran-6(2h)-one derivatives and uses thereof

The present invention relates to new pyrano[3,2-c]benzopyran-6(2H)-one derivatives that act as SGLT2 inhibitors, which makes them promising candidates for the treatment of diabetes and other diseases and conditions mediated by SGLT2. These new drugs also exhibit platelet aggregation inhibitory activity which makes them promising candidates in the treatment and/or prevention of prothrombotic conditions. The invention also relates to the use of such pyrano[3,2-c]benzopyran-6(2H)-one derivatives in the treatment or prevention of the diabetes and other disorders and conditions mediated by SGLT2, as a single active ingredient or in combination with another antidiabetic agent or a drug for the treatment of hypertension, chronic heart failure or atherosclerosis, and pharmaceutical compositions comprising said new pyrano[3,2-c]benzopyran-6(2H)-one derivatives.

BORON-CONTAINING SMALL MOLECULES

This invention provides novel compounds, methods of using the compounds, and pharmaceutical compositions containing the compounds.