74614-67-8

Basic information

• Product Name: α-(3-benzoylphenyl)acrylic acid
• Synonyms: α-(3-benzoylphenyl)acrylic acid
• CAS NO: 74614-67-8
• Molecular Weight: 252.269
• Mol File: 74614-67-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: α-(3-benzoylphenyl)acrylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: α-(3-benzoylphenyl)acrylic acid(74614-67-8)
• EPA Substance Registry System: α-(3-benzoylphenyl)acrylic acid(74614-67-8)

Safety Data

• Hazardous Substances Data: 74614-67-8(Hazardous Substances Data)

Upstream product

• 75116-78-8 ethyl α-(3-benzoylphenyl)acrylate 

Downstream Products

• 22161-81-5 S-ketoprofen 
• 56105-81-8 R-ketoprofen 
• 59960-32-6 Dihydroketoprofen 

Relevant articles and documents

ENANTIOSELECTIVE SYNTHESIS AND ABSOLUTE CONFIGURATION OF (+)-α-(3-BENZOYLPHENYL)PROPIONIC ACID

Asymmetric homogeneous hydrogenation of α-(3-benzoylphenyl)acrylic acid (4), which is preparared in 90percent overall yield from (3-benzoylphenyl)acetic acid (1), affords (+)-α-(3-benzoylphenyl)propionic acid, (+)-5, in 93.7percent chemical and 67.4percent optical yield.The absolute configuration of (+)-5 is correlated with that of (+)-(S)-hydratropic acid via (+)-α-(3-benzylphenyl)propionic acid, (+)-6.The origin of the CD bands of (+)-6 is discussed and comparison of chiroptical data with those of (+)-(S)-hydratropic acid, reveals that (+)-6 has an S configuration.Since (+)-6 is chemically correlated with (+)-5, the absolute S configuration of this enantiomer is confirmed.