7469-77-4Relevant articles and documents
Selective Oxidation of 2-Methylnaphthalene to 2-Methyl-1-naphthol by Rhodococcus sp. M192
Taguchi, Hisataka,Kita, Shunbun,Kobayashi, Motoo,Tani, Yoshiki
, p. 769 - 772 (1996)
About 6000 isolates of microorganisms assimilating methylketones (C3-C6) were tested for their selective oxidation of 2-methylnaphthalene to 2-methyl-1-naphthol. Strain M192 was the highest 2-methyl-1-naphthol producer and was classified as the genus Rhodococcus. The optimal conditions for the site-specific oxidation were studied using resting Rhodococcus sp. M192. The 2-methyl-1-naphthol productivity was specifically increased using methylethylketone as a carbon source, 1-propanol as a solvent to dissolve the substrate, and ethylxanthate or diethyldithiocarbamate as an inhibitor of 2-naphthoic acid (side-product) production. In the presence of these compounds, 2-methylnaphthalene was specifically oxidized at the 1-position without the conversion to 2-naphthoic acid. The productivity of 2-methyl-1-naphthol was about 90 μM from 1 mM 2-methylnaphthalene.
Controlling the Gold(I)-Catalyzed 1,5-Allenene Reaction: Construction of Fused Rings with Excellent Diastereoselectivity
Haberhauer, Gebhard,Semleit, Nina
supporting information, p. 9635 - 9639 (2021/12/06)
In the present study, the gold(I)-catalyzed reaction of 1,5-allenenes was controlled in such a way that instead of a [2 + 3] cycloaddition, a 5-exo-cyclization with the formation of a carbocation occurred. The latter could be trapped with both oxygen and carbon nucleophiles. In the investigated system, fused tricyclic frameworks with three contiguous stereocenters with excellent chemo- and diastereoselectivity in up to 95% yield were obtained.
Preparation method of menadione sodium hydrogen sulfite
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Paragraph 0058; 0072-0077, (2021/07/31)
The invention provides a preparation method of menadione sodium hydrogen sulfite. The preparation method comprises the following steps of: by taking alpha-methyl-gamma-butyrolactone and benzene as raw materials, preparing 2-methyl-3, 4-dihydro-1 (2H)-naphthalenone through Friedel-Crafts reaction; carrying out halogenation reaction on the 2-methyl-3, 4-dihydro-1 (2H)-naphthalenone and a halogenation reagent at the ortho position of carbonyl, and carrying out alkali elimination to prepare 2-methyl-1-naphthol; oxidizing the 2-methyl-1-naphthol through air to obtain 2-methyl-1, 4-naphthoquinone; and carrying out addition reaction on the 2-methyl-1, 4-naphthoquinone and sodium hydrogen sulfite to prepare the menadione sodium hydrogen sulfite. According to the method, the raw materials are cheap, easily available and low in cost; the process operation is safe, simple and convenient, less process wastewater is generated, and the method is green and environment-friendly; and the stability of the raw materials and intermediate products is high, high reaction activity and selectivity are high, reaction conditions are easy to realize, side reactions are few, the purity and yield of the product are high, and industrial production of the menadione sodium bisulfite can be facilitated.
Photocatalytic hydrogen evolution of 1-tetralones to α-naphthols by continuous-flow technology
He, Xu,Zheng, Yi-Wen,Lei, Tao,Liu, Wen-Qiang,Chen, Bin,Feng, Ke,Tung, Chen-Ho,Wu, Li-Zhu
, p. 3337 - 3341 (2019/07/10)
Taking advantage of the synergy between photocatalysis and cobaloxime catalysis, the keto-enol radical cation of 1-tetralones becomes compatible with the transformation of various 1-tetralones into α-naphthols and H2 by virtue of the continuous-flow approach without any sacrificial oxidants under unusually mild conditions.