74713-60-3 Usage
Uses
N-LAUROYL-D-ERYTHRO-SPHINGOSINE is used as a lipid standard in the optimization of liquid chromatography-mass spectrometry (LC-MS) method conditions. This application is due to its stability and specificity as a reference compound, allowing for accurate and reliable measurements in lipid analysis.
Used in Biomedical Research:
N-LAUROYL-D-ERYTHRO-SPHINGOSINE is used as an internal standard for lipid extraction in U87MG (human glioma cell line). Its role in this context is to ensure the accuracy and reproducibility of lipid extraction procedures, which is essential for studying the role of lipids in cancer cell biology.
Used in Analytical Chemistry:
N-LAUROYL-D-ERYTHRO-SPHINGOSINE is used as an internal standard for the quantification of ceramide using liquid chromatography-mass spectrometry (LC-MS) in rat tissues. This application is important for understanding the distribution and metabolism of ceramides in vivo, which can provide insights into their biological functions and potential as therapeutic targets.
Biochem/physiol Actions
Ceramides?are signaling sphingolipids, which are implicated in regulating stress responses and inflammation. It also regulates cell growth arrest, differentiation and apoptosis.
Check Digit Verification of cas no
The CAS Registry Mumber 74713-60-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,7,1 and 3 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 74713-60:
(7*7)+(6*4)+(5*7)+(4*1)+(3*3)+(2*6)+(1*0)=133
133 % 10 = 3
So 74713-60-3 is a valid CAS Registry Number.
74713-60-3Relevant articles and documents
Chiral combinatorial preparation and biological evaluation of unique ceramides for inhibition of sphingomyelin synthase
Koolath, Sajeer,Monde, Kenji,Murai, Yuta,Suga, Yoshiko
supporting information, (2020/02/04)
Enantiomers or diastereomers of chiral bioactive compounds often exhibit different biological and toxicological properties. Here, we report the efficient synthesis of four stereoisomers of sphingosine and derivatization of unique chiral ceramides through a combinatorial chemistry by solid-phase activated resin ester. In addition, to test the effectivity of stereochemistry of ceramide, we demonstrated a cell-based assay of sphingomyelin synthase inhibition in the presence ofchiral unique ceramides, which suggested that libraries of this sort will be a rich source of biologically active synthetic molecules.
The synthesis and biological characterization of a ceramide library
Chang, Young-Tae,Choi, Jaehwa,Ding, Sheng,Prieschl, Eva E.,Baumruker, Thomas,Lee, Jae-Mok,Chung, Sung-Kee,Schultz, Peter G.
, p. 1856 - 1857 (2007/10/03)
A facile synthesis of a combinatorial ceramide library and their activities in the NF-κB pathway and in apoptosis induction/prevention were demonstrated. A novel NF-κB activating molecule was discovered among ceramide containing β-galactose, and the structural requirements of ceramides for apoptosis induction was elucidated. Copyright
