7472-08-4Relevant articles and documents
Alkylating capacity and reaction products of antimalarial trioxanes after activation by a heme model
Cazelles, Jerome,Robert, Anne,Meunier, Bernard
, p. 609 - 619 (2002)
The reactivity of 1,2,4-trioxane molecules 2-5, structurally related to the antimalarial drug artemisinin, with a heme model, manganese(II) tetraphenylporphyrin, is reported. With the pharmacologically active drugs 2-4, covalent adducts were obtained by a