747353-15-7Relevant articles and documents
Synthesis, radiofluorination and pharmacological evaluation of a fluoromethyl spirocyclic PET tracer for central σ1 receptors and comparison with fluoroalkyl homologs
Maisonial, Aurélie,Gro?e Maestrup, Eva,Wiese, Christian,Hiller, Achim,Schepmann, Dirk,Fischer, Steffen,Deuther-Conrad, Winnie,Steinbach, J?rg,Brust, Peter,Wünsch, Bernhard
, p. 257 - 269 (2012/03/26)
The spirocyclic σ1 receptor ligand 1 (1′-benzyl-3- (fluoromethyl)-3H-spiro[[2]benzofuran-1,4′-piperidine]) was prepared in four steps starting from methoxy derivative 5. Due to its high σ1 affinity (Ki = 0.74 nM) and selec