7474-36-4

Basic information

• Product Name: N-cyclohexylcyclohexanecarboxamide
• Synonyms: cyclohexanecarboxamide, N-cyclohexyl-
• CAS NO: 7474-36-4
• Molecular Formula: C₁₃H₂₃NO
• Molecular Weight: 209.3278
• Mol File: 7474-36-4.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 380.3°C at 760 mmHg
• Flash Point: 229.3°C
• Density: 0.98g/cm³
• Vapor Pressure: 5.49E-06mmHg at 25°C
• Refractive Index: 1.496
• CAS DataBase Reference: N-cyclohexylcyclohexanecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclohexylcyclohexanecarboxamide(7474-36-4)
• EPA Substance Registry System: N-cyclohexylcyclohexanecarboxamide(7474-36-4)

Safety Data

• Hazardous Substances Data: 7474-36-4(Hazardous Substances Data)

Upstream product

• 108-91-8 cyclohexylamine 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 101-83-7 N-cyclohexyl-cyclohexanamine 
• 98-89-5 Cyclohexanecarboxylic acid 
• 4630-82-4 methyl cyclohexylcarboxylate 
• 110-83-8 cyclohexene 
• 70584-30-4 N-cyclohexyl-3,5-dimethyl-1H-pyrazole-1-carboxamide 
• 626-62-0 Cyclohexyl iodide 
• 1122-56-1 cyclohexylcarboxamide 
• 108-85-0 1-bromocyclohexane 
• 110-82-7 cyclohexane 
• 201230-82-2 carbon monoxide 
• 13939-06-5 molybdenum hexacarbonyl 
• 3173-53-3 Cyclohexyl isocyanate 

Downstream Products

• 3026-98-0 N-cyclohexyl-diacetamide 
• 1401412-98-3 N-(1-cyclohexylpentyl)cyclohexanamine 
• 1401412-99-4 N-(1-cyclohexyl-2-phenylethyl)cyclohexanamine 
• 87364-66-7 N-(Cyclohexylmethyl)-N-cyclohexylamine 
• 56037-75-3 N,1-dicyclohexylmethanimine dicyclohexyl imine 
• 138469-42-8 Cyclohexylcarboxaldehyde cyclohexylimine 

Relevant articles and documents

Synthesis and characterization of Pd(II)–vitamin B6 complex supported on magnetic nanoparticle as an efficient and recyclable catalyst system for C–N cross coupling of amides in deep eutectic solvents

Vitamin B6–Pd(II) immobilized onto magnetic nanoparticles have been successfully prepared and applied for C–Xcross-coupling reactions with aryl halides in green deep eutectic solvents. The results prove that the Fe3O4@vitamin B6–Pd(II) magnetic nanoparticles show high catalyst activity and good stability. It was also revealed that this complex can be recycled up to five times without any significant loss in catalytic activity.

Preparation method of fatty acid amide

The invention relates to a preparation method of fatty acid amide. The method includes: adding hydroxylamine hydrochloride, a transition metal, a phosphine ligand, olefin and a solvent into a high pressure reaction kettle in order, carrying out hydroamine

Nickel-catalyzed transamidation of aliphatic amide derivatives

Transamidation, or the conversion of one amide to another, is a long-standing challenge in organic synthesis. Although notable progress has been made in the transamidation of primary amides, the transamidation of secondary amides has remained underdeveloped, especially when considering aliphatic substrates. Herein, we report a two-step approach to achieve the transamidation of secondary aliphatic amides, which relies on non-precious metal catalysis. The method involves initial Boc-functionalization of secondary amide substrates to weaken the amide C-N bond. Subsequent treatment with a nickel catalyst, in the presence of an appropriate amine coupling partner, then delivers the net transamidated products. The transformation proceeds in synthetically useful yields across a range of substrates. A series of competition experiments delineate selectivity patterns that should influence future synthetic design. Moreover, the transamidation of Boc-activated secondary amide derivatives bearing epimerizable stereocenters underscores the mildness and synthetic utility of this methodology. This study provides the most general solution to the classic problem of secondary amide transamidation reported to date.