74879-13-3

Basic information

• Product Name: 1,5-DIMETHYLPIPERAZIN-2-ONE
• Synonyms: 1,5-DIMETHYLPIPERAZIN-2-ONE;1,5-Dimethylpiperazin-2-one ,98%;1,5-Dimethylpiperizin-2-one;1,5-Dimethyl-2-piperazinone;1,5-diMethylpiperazin-2-one hcl
• CAS NO: 74879-13-3
• Molecular Formula: C6H12N2O
• Molecular Weight: 128.1723
• Mol File: 74879-13-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 243℃
• Flash Point: 101℃
• Appearance: /
• Density: 0.985
• Vapor Pressure: 0.0323mmHg at 25°C
• Refractive Index: 1.449
• Storage Temp.: 2-8°C
• PKA: 7.49±0.40(Predicted)
• CAS DataBase Reference: 1,5-DIMETHYLPIPERAZIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-DIMETHYLPIPERAZIN-2-ONE(74879-13-3)
• EPA Substance Registry System: 1,5-DIMETHYLPIPERAZIN-2-ONE(74879-13-3)

Safety Data

• Hazardous Substances Data: 74879-13-3(Hazardous Substances Data)

Usage

General Description

1,5-DIMETHYLPIPERAZIN-2-ONE is a chemical compound commonly used in organic synthesis. It has a molecular formula of C6H12N2O and a molar mass of 128.174 g·mol?1. This synthetic chemical is often utilized in the preparation of pharmaceuticals, dyes, polymers, and other various chemical interactions. Not much is publicly known about its safety or environmental impact, indicating that handling should be done with caution until more research is available. Its properties include a boiling point of 91-92 °C (lit.), and it's slightly soluble in water.

InChI:InChI=1/C6H12N2O/c1-5-4-8(2)6(9)3-7-5/h5,7H,3-4H2,1-2H3

Upstream product

• 74879-12-2 1,5-dimethyl-2(1H)-pyrazinone 

Relevant articles and documents

10-Hydroxy-7,8-dihydropyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrid azine-1,9(2H,6H)-diones: Potent, orally bioavailable HIV-1 integrase strand-transfer inhibitors with activity against integrase mutants

A series of 10-hydroxy-7,8-dihydropyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrid azine-1,9(2H,6H)-diones was synthesized and tested for their inhibition of HIV-1 replication in cell culture. Structure-activity studies indicated that high antiviral potency against wild-type virus as well as viruses containing integrase mutations that confer resistance to three different structural classes of integrase inhibitors could be achieved by incorporation of small aliphatic groups at certain positions on the core template. An optimal compound from this study, 16, inhibits integrase strand-transfer activity with an IC50 value of ≤10 nM, inhibits HIV-1 replication in cell culture with an IC95 value of 35 nM in the presence of 50% normal human serum, and displays modest pharmacokinetic properties in rats (iv t1/2 = 5.3 h, F = 17%).

Absolute Configuration of 6-Methyl-5,6,7,8-tetrahydropterin produced by Enzymic Reduction (Dihydrofolate Reductase and NADPH) of 6-Methyl-7,8-dihydropterin

Dihydrofolate reductase (5,6,7,8-tetrahydrofolate: NADP oxidoreductase, E.C.1.5.1.3.) and NADPH, which catalyse the reduction of 7,8-dihydrofolic acid (1) stereospecifically to give one diastereoisomer of 5,6,7,8-tetrahydrofolic acid (3), also catalyse the reduction of 6-methyl-7,8-dihydropterin (2) stereospecifically to (-)-6-methyl-5,6,7,8-tetrahydropterin (4); the absolute configuration at C-6 of the pterin (4) is shown to be S by correlation with S-alanine using a series of methylations, degradations, and syntheses, and if the most probable assumption is made that the stereospecificities of these two reactions are the same, then the absolute configuration at C-6 of enzymically produced 5,6,7,8-tetrahydrofolic acid should be S.