74880-17-4

Basic information

• Product Name: 1-Benzyl-3-hydroxyimino-2-methylpyrrolidine
• Synonyms: 2-Methyl-1-(phenylmethyl)-3-pyrrolidinone Oxim;2-Methyl-1-(phenylmethyl)-3-pyrrolidinone Oxime
• CAS NO: 74880-17-4
• Molecular Formula: C₁₂H₁₆N₂O
• Molecular Weight: 204.27
• Product Categories: Aromatics Compounds;Aromatics;Intermediates
• Mol File: 74880-17-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Benzyl-3-hydroxyimino-2-methylpyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-3-hydroxyimino-2-methylpyrrolidine(74880-17-4)
• EPA Substance Registry System: 1-Benzyl-3-hydroxyimino-2-methylpyrrolidine(74880-17-4)

Safety Data

• Hazardous Substances Data: 74880-17-4(Hazardous Substances Data)

Usage

Chemical Properties

Beige Solid

Uses

A benzamide derivative

Upstream product

• 60584-77-2 (α-ethoxycarbonylethyl)-β-ethoxycarbonylethylbenzylamine 

Downstream Products

• 70325-82-5 cis-3-amino-1-benzyl-2-methylpyrrolidine 
• 70325-82-5 trans-3-amino-1-benzyl-2-methylpyrrolidine 
• 70325-83-6 N-((2S,3R)-1-Benzyl-2-methyl-pyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylamino-benzamide 
• 70325-83-6 Emilace 

Relevant articles and documents

Heterocyclization of oximes of 3,5-dimethyl(1,3,5-trimethyl)-2,6- diphenylpiperid-4-ones and N-benzylpyrrolid-3-ones with acetylene in a superbasic medium

It has been established that on heterocyclization of 3,5-dimethyl-2,6- diphenylpiperid-4-one oxime with acetylene in a superbasic medium migration of the 3a-CH3 group to the anionic nitrogen atom occurs, leading to the formation of 5,7-dimethyl-4,6-diphenyl-4,5,6,7-tetrahydropyrrolo[3,2-c]pyridine. The formation of the N-anion causes aromatization of the tetrahydropyridine ring. Tetrahydropyrrolo-[1,2-c]pyrimidines are formed in the Trofimov reaction as a result of decomposition of the intermediate 3H-pyrrole in a retro-Mannich reaction.