74974-54-2 Usage
Description
1,1,1-Trimethoxy-2-chloroethane, also known as 2-Chloro-1,1,1-trimethoxyethane, is a chloromethyl heterocyclic compound characterized by its unique chemical structure and reactivity. It is a versatile intermediate in the synthesis of various organic compounds and pharmaceuticals due to its distinct functional groups.
Uses
Used in Pharmaceutical Industry:
1,1,1-Trimethoxy-2-chloroethane is used as a synthetic intermediate for the production of chlorotriazolinone, an NK1 antagonist. 1,1,1-Trimethoxy-2-chloroethane is significant in the development of medications targeting neurokinin receptors, which play a role in various physiological processes and are implicated in conditions such as migraine, depression, and anxiety.
1,1,1-Trimethoxy-2-chloroethane is also used as a synthetic intermediate for the synthesis of 2-chloromethyl-7-[3-(trifluoromethyl)pyridin-2-yl]-3H-quinazolin-4-one. 1,1,1-Trimethoxy-2-chloroethane has potential applications in the development of new therapeutic agents, particularly in the treatment of various diseases and disorders.
Used in Chemical Synthesis:
In the field of chemical synthesis, 1,1,1-Trimethoxy-2-chloroethane is utilized as a key building block for the creation of 2-phenyl-1,3,4-oxadiazole derivatives. These derivatives are known for their diverse applications, including their use as pharmaceuticals, agrochemicals, and materials with unique properties such as fluorescence or conductivity.
Check Digit Verification of cas no
The CAS Registry Mumber 74974-54-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,9,7 and 4 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 74974-54:
(7*7)+(6*4)+(5*9)+(4*7)+(3*4)+(2*5)+(1*4)=172
172 % 10 = 2
So 74974-54-2 is a valid CAS Registry Number.
InChI:InChI=1/C5H11ClO3/c1-7-5(4-6,8-2)9-3/h4H2,1-3H3
74974-54-2Relevant articles and documents
Synthesis method of crude carboxylic ester (by machine translation)
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Paragraph 0021; 0022, (2020/08/09)
The method is characterized in that the carboxylic ester and the ether are prepared by reacting a carboxylic ester with an ether at a certain temperature under the catalysis of a catalyst at a certain pressure for a certain time. (by machine translation)
Divergent Diels-Alder methodology from methyl coumalate toward functionalized aromatics
Lee, Jennifer J.,Kraus, George A.
supporting information, p. 2366 - 2368 (2013/06/26)
An inverse electron-demand Diels-Alder reaction between methyl coumalate and electron-rich dienophiles produces substituted benzoates. A high-yielding, single-pot procedure transforms readily accessible vinyl ether, ketal, or orthoester dienophiles into functionalized aromatic systems in a versatile route.
A new synthesis of 1,2,4-triazolin-5-ones: Application to the convergent synthesis of an NK1 antagonist
Cowden,Wilson,Bishop,Cottrell,Davies,Dolling
, p. 8661 - 8664 (2007/10/03)
Chlorotriazolinone 4 has been synthesised in a single step via the novel condensation of semicarbazide hydrochloride with orthoester 8. Alkylation of secondary amine 3 with compound 4 proceeds in 99% yield to afford the target NK1 antagonist 1. (C) 2000 Published by Elsevier Science Ltd.