74974-61-1 Usage
Description
Aluminum trifluoromethanesulfonate, also known as triflic acid aluminum salt, is a white powder chemical compound with the formula (CF3SO3)3Al. It is a strong Lewis acid and is widely used as a catalyst in various organic reactions due to its high reactivity and stability.
Uses
1. Used in Organic Chemistry:
Aluminum trifluoromethanesulfonate is used as a Lewis acid catalyst for a variety of organic reactions, including Friedel-Crafts, ketalization, nucleophilic substitution, hydroalkoxylation, methoxycarbonylation, rearrangement, and epoxide ring-opening reactions. Its strong acidic properties and ability to coordinate with various substrates make it a versatile and effective catalyst in these processes.
2. Used in Pharmaceutical Industry:
Aluminum trifluoromethanesulfonate is also utilized in the synthesis of pharmaceutical intermediates. Its role as a catalyst in organic reactions allows for the efficient production of complex molecules that are essential in the development of various drugs and medications.
Preparation
Can be prepared from aluminum trichloride and tribromide by heating with triflic acid in anhydrous conditions. Preparations from triethylaluminum, aluminum carbide, and aluminum isopropoxide have also been described.
Reactions
Friedel-Crafts Reactions.
Aluminum trifluoromethanesulfonate has been used for the Friedel-Crafts alkylation reaction of toluene with isopropyl and tert-butyl chlorides (eq 1), and for theacylationofbenzeneandtoluenewithacetylandbenzoylchlo- rides in low to moderate yields. Intramolecular Friedel-Crafts acylation of an aromatic compound with Meldrum’s acid has also been reported using catalytic amounts of Al(OTf) 3 . Acylation of 2-methoxynaphthalene with acetic anhydride has been reported using Al(OTf) 3 and lithium perchlorate as an additive to afford the corresponding 6-acetylated adduct in 83% yield. Effective acylation of arenes with carboxylic acids has also been disclosed using polystyrene-supported Al(OTf)3.
Check Digit Verification of cas no
The CAS Registry Mumber 74974-61-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,9,7 and 4 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 74974-61:
(7*7)+(6*4)+(5*9)+(4*7)+(3*4)+(2*6)+(1*1)=171
171 % 10 = 1
So 74974-61-1 is a valid CAS Registry Number.
InChI:InChI=1/3CHF3O3S.Al/c3*2-1(3,4)8(5,6)7;/h3*(H,5,6,7);/q;;;+3/p-3