75110-48-4 Usage
Description
(3a,5b,6b,7b,12a)-3,6,7,12-tetrahydroxy-Cholan-24-oic acid, also known as Ursodeoxycholic acid (UDCA), is a bile acid naturally produced in the human body. It is characterized by its unique structure with four hydroxyl groups at positions 3, 6, 7, and 12, and a carboxylic acid group at position 24. UDCA plays a crucial role in the regulation of cholesterol and bile production, making it a vital component in the management of liver and gallbladder diseases.
Uses
Used in Pharmaceutical Industry:
UDCA is used as a therapeutic agent for the treatment of certain liver and gallbladder conditions, such as primary biliary cholangitis and gallstones. It functions by reducing cholesterol production in the liver and increasing bile production, which helps dissolve gallstones and improve liver function.
Used in Liver Function Improvement:
UDCA is used as a liver function enhancer, as it promotes the production of bile and reduces the amount of cholesterol produced by the liver. This helps maintain optimal liver function and overall health.
Used in Anti-inflammatory and Immunomodulatory Applications:
Due to its anti-inflammatory and immunomodulatory properties, UDCA is used as a potential treatment option for autoimmune and liver-related disorders. It modulates various signaling pathways and exhibits synergistic effects when combined with conventional therapies, enhancing their efficacy and sensitivity.
Used in Drug Research and Development:
UDCA continues to be a subject of research for potential new therapeutic applications, as its unique structure and properties offer promising avenues for the development of novel drugs and treatments for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 75110-48-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,1,1 and 0 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 75110-48:
(7*7)+(6*5)+(5*1)+(4*1)+(3*0)+(2*4)+(1*8)=104
104 % 10 = 4
So 75110-48-4 is a valid CAS Registry Number.
InChI:InChI=1/C24H40O6/c1-12(4-7-19(27)28)14-5-6-15-20-16(11-18(26)24(14,15)3)23(2)9-8-13(25)10-17(23)21(29)22(20)30/h12-18,20-22,25-26,29-30H,4-11H2,1-3H3,(H,27,28)/t12-,13-,14-,15+,16+,17+,18+,20+,21+,22-,23-,24-/m1/s1
75110-48-4Relevant articles and documents
Identification of 3,6,7,12-tetrahydroxy-5β-cholan-24-oic acids in human biologic fluids
Yoshii, Michiko,Kihira, Kenji,Shoda, Junichi,Osuga, Toshiaki,Hoshita, Takahiko
, p. 512 - 515 (1990)
Unusual bile acids, 3α,6α,7α,12α-, 3α,6β,7β,12α-, and 3α,6β,7β,12α-tetrahydroxy-5β-cholan-24-oic acids, were identified in all amniotic fluid (four samples) and urine (six samples) from adult patients with cholestalic liver disease by gas-liquid chromatography/mass spectrometry. For the certain identification of these bile acids in the biologic samples, the chemical syntheses of 3α,6β,7α,12α- and 3 α,6β,7β,12α-tetrahydroxy-5β-cholan-24-oic acids were conducted. (Steroids 55:512-515, 1990).
Potential bile acid metabolites. 16. Synthesis of stereoisomeric 3α,6,7,12α-tetrahydroxy-5β-cholanoic acids
Iida, Takashi,Komatsubara, Ichiro,Yoda, Seiichiro,Goto, Junichi,Nambara, Toshio,Chang, Frederic C.
, p. 530 - 539 (2007/10/02)
New synthetic routes to the four possible stereoisomeric 3α,6,7,12α-tetrahydroxy-5β-cholanoic acids (and their methyl esters), one of which (3α,6α,7β,12α) is new, and some related compounds are described.In addition, the 5α-epimer of the new acid was obtained.The final products were obtained in high purity for use as reference compounds in the analysis of bile acids in human biologic samples.The results of analysis of the prepared stereoisomers by proton and carbon 13 nuclear magnetic resonance spectroscopies are briefly discussed along with the thin-layer and gas-liquid chromatographic properties.
