75277-96-2Relevant articles and documents
Trifluoromethylation of Benzoic Acids: An Access to Aryl Trifluoromethyl Ketones
Liu, Xue,Liu, Long,Huang, Tianzeng,Zhang, Jingjing,Tang, Zhi,Li, Chunya,Chen, Tieqiao
supporting information, p. 4930 - 4934 (2021/06/30)
The trifluoromethylation of benzoic acids with TMSCF3 was achieved through nucleophilic substitution with the use of anhydrides as an in situ activating reagent. Under the reaction conditions, a wide range of carboxylic acids including the bioactive ones worked well, thus providing a facile and efficient method for preparing aryl trifluoromethyl ketones from the readily available starting materials.
Palladium-Catalyzed Trimethylenemethane Cycloaddition of Olefins Activated by the δ-Electron-Withdrawing Trifluoromethyl Group
Trost, Barry M.,Debien, Laurent
, p. 11606 - 11609 (2015/09/28)
α-Trifluoromethyl-styrenes, trifluoromethyl-enynes, and dienes undergo palladium-catalyzed trimethylenemethane cycloadditions under mild reaction conditions. The trifluoromethyl group serves as a unique δ-electron-withdrawing group for the activation of the olefin toward the cycloaddition. This method allows for the formation of exomethylene cyclopentanes bearing a quaternary center substituted by the trifluoromethyl group, compounds of interest for the pharmaceutical, agrochemical, and materials industries. In the diene series, the cycloaddition operates in a [3 + 4] and/or [3 + 2] manner to give rise to seven- and/or five-membered rings. This transformation greatly improves the scope of the TMM cycloaddition technology and provides invaluable insights into the reaction mechanism.
A facile synthesis of aryl trifluoromethyl ketones
Kerdesky,Basha
, p. 2003 - 2004 (2007/10/02)
The reaction of arylcopper reagents with α,α,α-trifluoroacetic anhydride gives the corresponding aryl trifluoromethyl ketones in good yields.
