75416-51-2

Basic information

• Product Name: 8-bromo-1,2,3,4-tetrahydroisoquinoline
• Synonyms: 8-bromo-1,2,3,4-tetrahydroisoquinoline;8-BroMo-1,2,3,4-tetrahydroisoquinline;Isoquinoline, 8-broMo-1,2,3,4-tetrahydro-;Isoquinoline, 8-bromo-1,2,3,4-tetrahydro-, hydrochloride (1:1)
• CAS NO: 75416-51-2
• Molecular Formula: C₉H₁₀BrN
• Molecular Weight: 212.0864
• EINECS: -0
• Mol File: 75416-51-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 294℃
• Flash Point: 132℃
• Appearance: /
• Density: 1.428
• Storage Temp.: 2-8°C(protect from light)
• PKA: 8.88±0.20(Predicted)
• CAS DataBase Reference: 8-bromo-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 8-bromo-1,2,3,4-tetrahydroisoquinoline(75416-51-2)
• EPA Substance Registry System: 8-bromo-1,2,3,4-tetrahydroisoquinoline(75416-51-2)

Safety Data

• Hazardous Substances Data: 75416-51-2(Hazardous Substances Data)

Usage

Uses

8-Bromo-1,2,3,4-tetrahydroisoquinoline is a useful intermediate for organic synthesis.

Upstream product

• 252331-63-8 1-(6-bromo-3,4-dihydro-1H-isoquinolin-2-yl)-2,2,2-trifluoro-ethanone 
• 726136-49-8 1-(8-bromo-3,4-dihydro-1H-isoquinolin-2-yl)-2,2,2,-trifluoro-ethanone 
• 63927-22-0 8-bromo-isoquinoline 

Downstream Products

• 893566-75-1 tert-butyl 8-bromo-1,2,3,4-tetrahydroisoquinoline-2-carboxylate 
• 893566-74-0 6-bromo-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

AZABENZIMIDAZOLE DERIVATIVES AS PI3K BETA INHIBITORS

The present invention relates to azabenzimidazole derivatives of Formula (I) (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3Kβ inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active 10 ingredient as well as the use of said compounds as a medicament.

HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF

The invention relates to the use of compounds in the treatment of deacetylase-associated diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases.

NOVEL COMPOUNDS

The invention provides compounds of formula (I): wherein R1, R2, A, A1 and B are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the ph