754167-24-3

Basic information

• Product Name: 3-(N,N-Diethylamino)-L-alanine
• Synonyms: D-SS-(N,N-DIETHYLAMINO)ALANINE;L-Alanine, 3-(diethylamino)- (9CI);D-β-(N,N-diethylamino) alanine;(S)-2-Amino-3-(diethylamino)propanoic acid;3-(N,N-Diethylamino)-L-alanine
• CAS NO: 754167-24-3
• Molecular Formula: C7H16N2O2
• Molecular Weight: 160.21
• Product Categories: AMINETERTIARY;GLYCINESCAFFOLD;Amino Acids
• Mol File: 754167-24-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 246.8 °C at 760 mmHg
• Flash Point: 103 °C
• Appearance: /
• Density: 1.067 g/cm³
• Refractive Index: 1.488
• PKA: 1.95±0.10(Predicted)
• CAS DataBase Reference: 3-(N,N-Diethylamino)-L-alanine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(N,N-Diethylamino)-L-alanine(754167-24-3)
• EPA Substance Registry System: 3-(N,N-Diethylamino)-L-alanine(754167-24-3)

Safety Data

• Hazardous Substances Data: 754167-24-3(Hazardous Substances Data)

Usage

General Description

3-(N,N-Diethylamino)-L-alanine is a chemical compound with the molecular formula C10H20N2O3. It is an amino acid derivative that contains a diethylamino group attached to the alanine molecule. 3-(N,N-Diethylamino)-L-alanine is commonly used in organic synthesis and pharmaceutical research due to its versatile chemical properties. It has been studied for its potential applications in drug development and medicinal chemistry. The diethylamino group in 3-(N,N-Diethylamino)-L-alanine makes it a useful building block for the creation of novel molecules and pharmaceutical compounds. Additionally, it has shown potential as a catalyst in certain chemical reactions due to its unique structure and reactivity. Overall, 3-(N,N-Diethylamino)-L-alanine has garnered interest in the scientific community for its potential in various chemical and pharmaceutical applications.

InChI:InChI=1/C7H16N2O2/c1-3-9(4-2)5-6(8)7(10)11/h6H,3-5,8H2,1-2H3,(H,10,11)/t6-/m0/s1

Upstream product

• 40055-77-4 2-Diaethyl-amino-1-acetyl-DL-alanin 
• 52-90-4 L-Cysteine 
• 109-89-7 diethylamine 

Relevant articles and documents

N-Salicylideneamino acidato complexes of oxovanadium(IV). the cysteine and penicillamine complexes

Oxovanadium(iv) complexes with ligands derived from the reaction of salicylaldehyde with L-cysteine and with D- and D,L-penicillamine are prepared. The compounds are characterised by elemental analysis, spectroscopy (UV-VIS, CD, EPR), TG, DSC and magnetic susceptibility measurements (9-295 K). We discuss several aspects related to the structure of these complexes in the solid state and in solution; in particular, the possibility of forming thiazolidine complexes, and their comparison with the characterised complexes is studied by molecular mechanics and density functional theory calculations. The solution structures depend on pH and solvent, and while with L-Cys the spectroscopic results show trends similar to those of the L-Ala and L-Ser systems up to ca. pH 8-9, where thiolate coordination starts being detected, the penicillamine system is quite distinct, namely thiolate coordination occurs for pH > 6.5. In the presence of salicylaldehyde and VIVO the desulfydration of cysteine proceeds rapidly, but no similar reaction occurs with penicillamine, although its decomposition is also activated. The DFT calculations do not indicate any energetic basis for this distinct reactivity, which possibly results from different complexes present in the Cys and Pen systems. In the cysteine system, the N-salicylidene dehydroalanine-VIVO complex V is believed to form in an intermediate stage of the desulfydration. Further, addition of several nucleophiles to the cysteine reaction mixtures produce amino acid derivatives by a Michael-type base-catalysed addition, a result compatible with the formation of V. The products of these reactions were analysed by TLC and HPLC, and in some cases isolated.