754183-64-7

Basic information

• Product Name: (S)-5-(benzo[1,3]dioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidin-2-one
• Synonyms: (S)-5-(benzo[1,3]dioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidin-2-one
• CAS NO: 754183-64-7
• Molecular Weight: 343.355
• Mol File: 754183-64-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-5-(benzo[1,3]dioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-5-(benzo[1,3]dioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidin-2-one(754183-64-7)
• EPA Substance Registry System: (S)-5-(benzo[1,3]dioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidin-2-one(754183-64-7)

Safety Data

• Hazardous Substances Data: 754183-64-7(Hazardous Substances Data)

Upstream product

• 533-31-3 Sesamol 
• 1229652-94-1 (S)-methanesulfonic acid 4-(4-fluorophenyl)-6-oxopiperidin-3-ylmethyl ester 

Downstream Products

• 61869-08-7 paroxetine 

Relevant articles and documents

Synthesis of (-)-paroxetine via enantioselective phase-transfer catalytic monoalkylation of malonamide ester

(Figure presented) A new enantioselective synthetic method of (-)-paroxetine is reported. (-)-Paroxetine could be obtained in 15 steps (95% ee and 9.1% overall yield) from N,N-bis(p-methoxyphenyl)malonamide tert-butyl ester via the enantioselective phase-transfer catalytic alkylation and the diastereoselective Michael addition as the key steps.