75424-63-4

Basic information

• Product Name: 5-oxo-5-phenylpentanal
• Synonyms: 5-oxo-5-phenylpentanal
• CAS NO: 75424-63-4
• Molecular Weight: 176.215
• Mol File: 75424-63-4.mol
• Article Data: 39

Chemical Properties

• Boiling Point: 110-116 °C(Press: 0.2 Torr)
• Density: 1.050±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 5-oxo-5-phenylpentanal(CAS DataBase Reference)
• NIST Chemistry Reference: 5-oxo-5-phenylpentanal(75424-63-4)
• EPA Substance Registry System: 5-oxo-5-phenylpentanal(75424-63-4)

Safety Data

• Hazardous Substances Data: 75424-63-4(Hazardous Substances Data)

Upstream product

• 825-54-7 cyclopent-1-en-1-ylbenzene 
• 64-19-7 acetic acid 
• 67-56-1 methanol 
• 23253-31-8 1-phenyl-6,7,8-trioxa-bicyclo<3.2.1>octane 
• 77116-24-6 C₁₁H₁₂Cl₅O₃Sb 
• 23253-31-8 1-phenylcyclopentene ozonide 
• 72328-15-5 cis-3,6-bis(3-benzoylpropyl)-1,2,4,5-tetroxane 
• 1011-62-7 5-hydroxy-1-phenylpentan-1-one 
• 20913-05-7 (Benzoylmethylene)triphenylphosphorane 
• 198977-95-6 (E)-5-{tert-butyl(dimethyl)silyloxy}-1-phenyl-2-penten-1-one 
• 946523-96-2 (E)-5-hydroxy-1-phenylpent-2-en-1-one 
• 1011-61-6 1-phenylpentane-1,5-diol 
• 176853-29-5 5,5-dimethoxy-5-phenylpentanal dimethyl acetal 
• 6651-43-0 1-(trimethylsiloxy)-1,3-butadiene 

Downstream Products

• 131221-80-2 1-phenyl-1,2-dihydroxycyclopentane 
• 112607-33-7 (+)-(R)-δ-(phenyl)-δ-valerolactone 
• 353460-45-4 ethyl (E)-7-oxo-7-phenylhept-2-enoate 
• 40297-30-1 2-Hydroxy-2-phenylcyclopentan-1-one 
• 98-86-2 acetophenone 
• 1008-89-5 2-phenylpyridine 
• 156271-17-9 (S)-3-Methyl-2-((S)-2-phenyl-piperidin-1-yl)-butyric acid methyl ester 
• 942-92-7 caprophenone 

Relevant articles and documents

Iron-Catalyzed Ring-Opening Reactions of Cyclopropanols with Alkenes and TBHP: Synthesis of 5-Oxo Peroxides

The ring opening of cyclopropanols is rarely used in multicomponent reactions. Herein we report the three-component reaction of cyclopropanols with alkenes and tert-butyl hydroperoxide (TBHP) catalyzed by an iron catalyst. This protocol enables the incorporation of both the β-carbonyl fragment and a peroxy unit across the C=C double bond regioselectively, thus allowing an efficient, facile access to 5-oxo peroxides. Modification of the biologically active molecules and various downstream derivatizations of the peroxides are also demonstrated.

Generation of alkyl radicals from alkylsilyl peroxides and their applications to C-N or C-O bond formations

This article describes a novel method for the generation of alkyl radicals from alkylsilyl peroxides and their applications to the Cu-catalyzed mono-N-alkylation of amides or arylamines, and to the O-alkylation of carboxylic acids. The use of alkylsilyl peroxides as alkyl radical sources includes the following synthetic advantages: i) various alkylsilyl peroxides can be readily synthesized from the corresponding alcohols and be stored at bench, and ii) a variety of alkyl radicals can be generated efficiently under mild conditions.

Alkylsilyl Peroxides as Alkylating Agents in the Copper-Catalyzed Selective Mono-N-Alkylation of Primary Amides and Arylamines

The copper-catalyzed selective mono-N-alkylation of primary amides or arylamines using alkylsilyl peroxides as alkylating agents is reported. The reaction proceeds under mild reaction conditions and exhibits a broad substrate scope with respect to the alkylsilyl peroxides, as well as to the primary amides and arylamines. Mechanistic studies suggest that the present reaction should proceed through a free-radical process that includes alkyl radicals generated from the alkylsilyl peroxides.