75447-71-1Relevant articles and documents
Quantitative Evaluation of the Reactivity of Alkylating Agents
Bodor, Nicholas,Kaminski, James J.,Worley, S. D.,Gerson, Steven H.
, p. 758 - 763 (2007/10/02)
A sensitive and reproducible method for quantitative evaluation of the relative reactivities of alkylating agents was developed, based on competitive alkylation.The method is superior to the known calorimetric methods.The reactivities of the agents could also be correlated with the 13C chemical shifts of the α-methylene.The method was successfully applied for the ranking of "soft" alkylating agents of low reactivity. - Keywords: Alkylating Agents, Soft Drugs, NMR Spectra, Competitive Alkylation, Soft Quaternary Salts