75476-79-8

Basic information

• Product Name: 1H-Indene, 5-iodo-
• CAS NO: 75476-79-8
• Molecular Formula: C9H7I
• Molecular Weight: 242.05600
• Mol File: 75476-79-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Indene, 5-iodo-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indene, 5-iodo-(75476-79-8)
• EPA Substance Registry System: 1H-Indene, 5-iodo-(75476-79-8)

Safety Data

• Hazardous Substances Data: 75476-79-8(Hazardous Substances Data)

Usage

Structure

Bicyclic aromatic hydrocarbon with one iodine atom attached

Usage

Building block in the synthesis of pharmaceuticals and agrochemicals, intermediate in the production of organic compounds and dyes

Reactivity

Highly reactive, can undergo halogenation, oxidation, and reduction reactions

Environmental and health hazards

Potential risks, must be handled and disposed of with caution.

Upstream product

• 75476-85-6 5-Aminoindene 
• 75476-81-2 6-Iodoindene 
• 14548-40-4 6-iodo-2,3-dihydro-1H-inden-1-one 
• 83-33-0 inden-1-one 
• 24623-24-3 6-nitroindan-1-one 
• 69975-65-1 6-aminoindan-1-one 
• 41734-55-8 5-nitro-1H-indene 

Downstream Products

• 75476-83-4 7-Iodoisoquinoline 
• 232-55-3 3H-Benzindene 
• 268-40-6 benz [f]indene 

Relevant articles and documents

Synthesis of haloindenes

The subject invention provides an expedited synthesis of 5, 6, and 7-iodoindenes from the corresponding aminoindan-1-ones in more than 70% yield, employing readily available precursors and reagents. A three-step sequence involves diazotization-iodination of aminoindan-1-one followed by reduction and dehydration. The method has a general character and can be extended for the preparation of various 4-, 5-, 6- or 7-haloindenes using different halogen sources for diazotization-halogenation reaction.

Synthesis of Isoquinolines from Indenes

A general procedure for the synthesis of isoquinolines from appropriately substituted indenes is described.Ozonolysis of the indenes followed by reductive workup gives intermediate homophthalaldehydes which are treated with ammonium hydroxide to give the isoquinolines.This "one-pot", three-step reaction sequence was applied to the formation of all of the mono-C-methyl-substituted isoquinolines in a regiospecific manner.The procedure is applicable to both electron-withdrawing and electron-donating substituents on the indene system.In this manner the 6- and 7-nitro-,-bromo-, and -iodoisoquinolines were prepared.