7552-07-0

Basic information

• Product Name: 5-Amino-1,2,4-thiadiazole
• Synonyms: 5-AMINO-1,2,4-THIADIAZOLE;1,2,4-THIADIAZOL-5-AMINE;1,2,4-THIADIAZOL-5-YLAMINE;1,2,4-Thiadiazole, 5-amino-;1,2,4-Thiadiazol-5-amine(9CI);[1,2,4]Thiadiazol-5-ylaMine hydrochloride;[1,2,4]Thiadiazol-5-ylaMine.HCl;1,2,4-Thiadiazole-5-aMine
• CAS NO: 7552-07-0
• Molecular Formula: C₂H₃N₃S
• Molecular Weight: 101.13
• Product Categories: VARIOUSAMINE
• Mol File: 7552-07-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 112-115°C
• Boiling Point: 2.8 °C at 760 mmHg
• Flash Point: 98.3°C
• Appearance: /
• Density: 0.692 g/cm³
• Vapor Pressure: 0.0412mmHg at 25°C
• Refractive Index: 1.662
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.97±0.50(Predicted)
• CAS DataBase Reference: 5-Amino-1,2,4-thiadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-1,2,4-thiadiazole(7552-07-0)
• EPA Substance Registry System: 5-Amino-1,2,4-thiadiazole(7552-07-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/22
• Safety Statements: S22:Do not inhale dust.; S36/37:Wear suitable protective clothing and gloves.
• HazardClass: IRRITANT
• Hazardous Substances Data: 7552-07-0(Hazardous Substances Data)

Usage

Description

5-Amino-1,2,4-thiadiazole is an organic compound with the molecular formula C2H3N3S. It is a heterocyclic compound featuring a thiadiazole ring with an amino group attached to one of the carbon atoms. 5-Amino-1,2,4-thiadiazole is known for its versatile chemical properties and is widely utilized in various chemical and pharmaceutical applications.

Uses

Used in Organic Synthesis:
5-Amino-1,2,4-thiadiazole is used as a key intermediate in the synthesis of various organic compounds. Its unique structure allows for a range of chemical reactions, making it a valuable building block for the development of new molecules with potential applications in various industries.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 5-Amino-1,2,4-thiadiazole is used as a research chemical for the development of new drugs. Its chemical properties enable it to be incorporated into drug molecules, potentially enhancing their efficacy and selectivity. Researchers utilize this compound to explore its potential in the treatment of various diseases and conditions.
Used in Chemical Processes:
5-Amino-1,2,4-thiadiazole is also employed in various chemical processes, such as the production of dyes, pigments, and other specialty chemicals. Its reactivity and stability make it a suitable candidate for use in the synthesis of these materials, contributing to the development of new products with improved properties.

Physical Form

Solid

InChI:InChI=1/C2H3N3S/c3-2-4-1-5-6-2/h1H,(H2,3,4,5)

Upstream product

• 115948-81-7 N-chloro-formamidine 
• 333-20-0 potassium thioacyanate 
• 6313-33-3 formamidine hydrochloride 
• 67-56-1 methanol 
• 7726-95-6 bromine 
• 463-52-5 formamidine 
• 943653-32-5 2-amino-4-dimethylamino-1,3-thiazabuta-1,3-diene 
• 3473-63-0 formamidine acetic acid 
• 152513-91-2 5-amino-1,2,4-thiadiazole hydrochloride 

Downstream Products

• 38362-15-1 5-chloro-1,2,4-thiadiazole 
• 94863-56-6 [1,2,4]thiadiazol-5-yl-trityl-amine 
• 91344-35-3 C-phenyl-N,N'-bis-[1,2,4]thiadiazol-5-yl-methanediamine 
• 90323-42-5 benzylidene-[1,2,4]thiadiazol-5-yl-amine 
• 63682-70-2 5-methyl-6-phenyl-imidazo[1,2-d][1,2,4]thiadiazole 
• 103274-67-5 5-(2,4-dimethyl-phenylazo)-[1,2,4]thiadiazole 
• 63682-63-3 2-(5-imino-[1,2,4]thiadiazol-4-yl)-1-phenyl-ethanone 
• 63682-65-5 2-(5-imino-[1,2,4]thiadiazol-4-yl)-1-(4-methoxy-phenyl)-ethanone 
• 103907-06-8 5-(2,4,6-trimethyl-phenylazo)-[1,2,4]thiadiazole 
• 2007-19-4 1-nitroso-2-naphthol-3,6-disulfonic acid 
• 43201-13-4 5-bromo-1,2,4-thiadiazole 
• 1039744-11-0 tert-butyl 1'-{4-[(1,2,4-thiadiazol-5-ylamino)carbonyl] phenyl}-4,4'-bipiperidine-1-carboxylate 
• 1079394-26-5 N-(4-(4-(1,2,4-thiadiazol-5-ylamino)-6-chloropyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide 
• 1079394-30-1 N-(4-(4-(1,2,4-thiadiazol-5-ylamino)-6-chloropyrimidin-2-ylthio)phenyl)-2-chlorobenzamide 

Relevant articles and documents

Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes

The discovery and selection of a highly potent and selective NaV1.7 inhibitor PF-06456384, designed specifically for intravenous infusion, is disclosed. Extensive in vitro pharmacology and ADME profiling followed by in vivo preclinical PK and efficacy model data are discussed. A proposed protein–ligand binding mode for this compound is also provided to rationalise the high levels of potency and selectivity over inhibition of related sodium channels. To further support the proposed binding mode, potent conjugates are described which illustrate the potential for development of chemical probes to enable further target evaluation.

HETEROCYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS

The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

2-amino-4-dimethylamino-1-thia-3-azabutadienes as precursors of thiazoles

The reaction of 2-amino-4-dimethylamino-1-thia-3-azabutadienes 1 with α-bromoketones gave rise to 2-aminothiazoles 2 together with 2-(N,N-dimethylaminomethylenamino)thiazoles 3. Competitive mechanisms are described. Furthermore, reaction of diene 1a with