75520-41-1

Basic information

• Product Name: ACETYL COENZYME A TRILITHIUM SALT
• Synonyms: ACETYL-S-COA LI3;ACETYL-COENZYME A, TRILITHIUM;ACETYL COENZYME A TRILITHIUM SALT;ACETYL COENZYME A, LITHIUM;ACETYL COENZYME A LITHIUM SALT;ACETYL-COA TRILITHIUM SALT;ACETYL-COA LI3;C2:0
• CAS NO: 75520-41-1
• Molecular Formula: C23H35Li3N7O17P3S
• Molecular Weight: 827.37
• EINECS: 200-790-9
• Mol File: 75520-41-1.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• Solubility: Soluble in water (10 mg/ml)
• Stability: Stable for 2 years as supplied. Solutions in water may be stored at -20°C for up to 2 weeks.
• CAS DataBase Reference: ACETYL COENZYME A TRILITHIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: ACETYL COENZYME A TRILITHIUM SALT(75520-41-1)
• EPA Substance Registry System: ACETYL COENZYME A TRILITHIUM SALT(75520-41-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37
• WGK Germany: 3
• F: 3-10-21
• Hazardous Substances Data: 75520-41-1(Hazardous Substances Data)

Usage

Description

Acetyl-CoA (75520-41-1), also known as Acetyl Coenzyme A Trilithium Salt, is an essential cofactor for cellular metabolism. It serves as an 'activated acetate' that facilitates the transfer of its moieties during anabolic, catabolic, and metabolic processes involving crucial molecules such as fatty acids, amino acids, glucose, and ATP. In the laboratory, it is used as a substrate in various assays, including chloramphenicol acetyltransferase (CAT) transcription reporter assays and histone acetyltransferase (HAT) assays in epigenetics research. It is a white amorphous powder.

Uses

1. Used in Enzymatic Acetyl Transfer Reactions:
Acetyl Coenzyme A Trilithium Salt is used as a crucial molecule for enzymatic acetyl transfer reactions, playing a significant role in various biological processes.
2. Used in Cellular Metabolism:
It acts as an essential cofactor, participating in anabolic, catabolic, and metabolic processes involving fundamental molecules like fatty acids, amino acids, glucose, and ATP.
3. Used in Laboratory Research:
Acetyl Coenzyme A Trilithium Salt is used as a substrate in chloramphenicol acetyltransferase (CAT) transcription reporter assays, which are essential for studying gene expression and regulation.
4. Used in Epigenetics Research:
It is also utilized in histone acetyltransferase (HAT) assays, which are vital for understanding the role of histone acetylation in gene regulation and its implications in various diseases.
5. Used in the Synthesis of Prosthetic Groups:
Acetyl Coenzyme A Trilithium Salt is the source of the phosphopantetheine group, which is added as a prosthetic group to acyl carrier proteins and formyltetrahydrofolate dehydrogenase, contributing to their function in cellular metabolism.

References

Wolfe (2005), The acetate switch; Mol. Biol. Rev. 69 12 Gorman et al. (1982), Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells; Mol. Cell Biol. 2 1044 Kim et al. (2000), A continuous, nonradioactive assay for histone acetyltransferases; Anal. Biochem. 280 308