7561-54-8Relevant articles and documents
Synthesis of new dinucleotide mRNA Cap analogs containing 2, 6-diaminopurine moiety
Kore, Anilkumar R.,Charles, Irudaya
, p. 200 - 202 (2010)
The first example of the synthesis of cap analog derivatives having 2, 6-diaminopurine nucleoside has been described. The desired modified cap analogs m7G[5']ppp[5']2-aminoA 6 and m2 7,3'°G[5']ppp[5']2-aminoA 7 were obtained from the coupling reaction of imidazolide salt of 2-amino adenosine [5'] monophosphate with its corresponding TEA salt of m7GDP in the presence of ZnCl2 as a catalyst in 73% and 64% yield, respectively. The structures of new cap analogs were confirmed by LC/MS, 1H and 31P NMR.
Synthesis of pyrophosphates for in vitro selection of catalytic RNA molecules
Kim, Hyo-Joong,Kim, Myong Jung,Karalkar, Nilesh,Hutter, Daniel,Benner, Steven A.
, p. 43 - 56 (2008/09/18)
Reported here are synthetic routes to pyrophosphates linking riboflavin with various nucleosides. The focus is on a flavin-uracil dinucleotide having a biotin tag on the uracil, a molecule that has potential value in the selection of RNA enzymes that catalyze the template-directed polymerization of RNA in the 3′-to-5′ direction, which is the direction opposite that catalyzed by standard protein polymerases. Two detailed procedures are presented to prepare this new compound, as well as one procedure to prepare the new flavin-2,6-diaminopurine dinucleotide. Copyright Taylor & Francis Group, LLC.
