75618-33-6

Basic information

• Product Name: 1,9(2H,10H)-Acridinedione, 7-chloro-3-(3,4-dichlorophenyl)-3,4-dihydro-10-hydroxy-
• CAS NO: 75618-33-6
• Molecular Formula: C19H12Cl3NO3
• Molecular Weight: 408.668
• Mol File: 75618-33-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,9(2H,10H)-Acridinedione, 7-chloro-3-(3,4-dichlorophenyl)-3,4-dihydro-10-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,9(2H,10H)-Acridinedione, 7-chloro-3-(3,4-dichlorophenyl)-3,4-dihydro-10-hydroxy-(75618-33-6)
• EPA Substance Registry System: 1,9(2H,10H)-Acridinedione, 7-chloro-3-(3,4-dichlorophenyl)-3,4-dihydro-10-hydroxy-(75618-33-6)

Safety Data

• Hazardous Substances Data: 75618-33-6(Hazardous Substances Data)

Upstream product

• 27463-42-9 5-(3,4-dichlorophenyl)-1,3-cyclohexanedione 
• 552-89-6 2-nitro-benzaldehyde 

Downstream Products

• 144128-42-7 7-Chloro-3-(3,4-dichloro-phenyl)-1-[(E)-1-ethyl-piperidin-3-ylimino]-10-hydroxy-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 80092-38-2 7-Chloro-3-(3,4-dichloro-phenyl)-10-hydroxy-1-[(E)-3-piperidin-1-yl-propylimino]-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 80108-14-1 7-Chloro-3-(3,4-dichloro-phenyl)-10-hydroxy-1-[(E)-3-(4-methyl-piperazin-1-yl)-propylimino]-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 80092-48-4 1-[(E)-3-Butylamino-propylimino]-7-chloro-3-(3,4-dichloro-phenyl)-10-hydroxy-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 80092-44-0 7-Chloro-3-(3,4-dichloro-phenyl)-10-hydroxy-1-[(E)-3-(2-hydroxy-ethylamino)-propylimino]-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 102192-42-7 7-Chloro-3-(3,4-dichloro-phenyl)-1-[(2-diethylamino-ethyl)-hydrazono]-10-hydroxy-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 144128-30-3 7-Chloro-3-(3,4-dichloro-phenyl)-10-hydroxy-3,4-dihydro-2H,10H-acridine-1,9-dione 1-[O-(2-diethylamino-ethyl)-oxime] 
• 80092-50-8 7-Chloro-3-(3,4-dichloro-phenyl)-1-[(E)-3-diethylamino-2,2-dimethyl-propylimino]-10-hydroxy-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 80092-49-5 7-Chloro-3-(3,4-dichloro-phenyl)-1-{(E)-3-[ethyl-(2-hydroxy-ethyl)-amino]-propylimino}-10-hydroxy-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 80092-42-8 7-Chloro-3-(3,4-dichloro-phenyl)-1-[(E)-2-diisobutylamino-ethylimino]-10-hydroxy-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 80092-41-7 7-Chloro-3-(3,4-dichloro-phenyl)-1-{(E)-2-[ethyl-(2-hydroxy-2-methyl-propyl)-amino]-ethylimino}-10-hydroxy-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 80092-37-1 7-Chloro-3-(3,4-dichloro-phenyl)-1-[(E)-7-dimethylamino-heptylimino]-10-hydroxy-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 144128-43-8 7-Chloro-3-(3,4-dichloro-phenyl)-1-[(E)-4-diethylamino-cyclohexylimino]-10-hydroxy-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 144128-45-0 7-Chloro-3-(3,4-dichloro-phenyl)-1-[(E)-3-diethylaminomethyl-phenylimino]-10-hydroxy-1,3,4,10-tetrahydro-2H-acridin-9-one 

Relevant articles and documents

Synthesis and Antimalarial Properties of 1-Imino Derivatives of 7-Chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and Related Structures

To improve upon the activity and properties of the 3-aryl-7-chloro-3,4-dihydro-1,9(2H,10H)-acridinediones, a variety of 1-imino derivatives (3) were prepared and shown to be highly active antimalarial agents in both rodents and primates.Among structural modifications prepared, including N10-alkyl and C2-substituted analogs, removal of the C9 oxygen, and introduction of an imino side chain at C9, the imines of the N10-H acridinediones were the most active compounds obtained.The imino derivative of7-chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1,9(2H,10H)-acridinedione (9aa) proved to be highly active in advanced studies in primates.

10-Hydroxy-3,4-dihydroacridine-1,9(2H,10H)-diones: a new group of malaricidal and coccidiostatic compounds

2-Nitrobenzaldehydes and 1,3-cyclohexanediones condense in a mixture of hydrocholic acid and glacial acetic acid to 10-hydroxy-3,4-dihydroacridine-1,9(2H,10H)-diones. Many compounds of this group reveal a pronounced coccidiostatic and malaricidal effect i