7578-45-2

Basic information

• Product Name: 4-Chloro-N-phenylbutyraMide, 97%
• Synonyms: 4-Chloro-N-phenylbutyraMide, 97%
• CAS NO: 7578-45-2
• Molecular Formula: C₁₀H₁₂ClNO
• Molecular Weight: 197.66138
• Mol File: 7578-45-2.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Chloro-N-phenylbutyraMide, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-N-phenylbutyraMide, 97%(7578-45-2)
• EPA Substance Registry System: 4-Chloro-N-phenylbutyraMide, 97%(7578-45-2)

Safety Data

• Hazardous Substances Data: 7578-45-2(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 4635-59-0 4-Chlorobutanoyl chloride 
• 19103-81-2 4-chlorobutanoylisothiocyanate 
• 927-58-2 4-bromobutyroyl chloride 
• 538-51-2 benzylidene phenylamine 
• 96-48-0 4-butanolide 
• 98-95-3 nitrobenzene 
• 593-71-5 Chloroiodomethane 
• 2210-24-4 N-acryloylaniline 

Downstream Products

• 4641-57-0 1-phenylpyrrolidin-2-one 
• 73963-34-5 5-(3-chloropropyl)-1-phenyl-1H-tetrazole 
• 58982-96-0 N-Phenyl-γ-butyrothiolactam 
• 186667-90-3 diethyl (1-phenylpyrrolidin-2-ylidene)malonate 
• 181959-63-7 4-acetylthio-N-phenylbutyrylamide 
• 950124-65-9 C₁₉H₁₇N₅OS 
• 926310-13-6 4-azido-N-phenyl-butyramide 
• 91012-01-0 4-Hydroxy-N-phenylbutyramide 
• 223394-90-9 N-phenyl-tetramethylenediamine 
• 112539-09-0 4-(2-oxopyrrolidin-1-yl)benzene-1-sulfonyl chloride 

Relevant articles and documents

Hydrofluoromethylation of alkenes with fluoroiodomethane and beyond

A process for the direct hydrofluoromethylation of alkenes is reported for the first time. This straighforward silyl radical-mediated reaction utilises CH2FI as a non-ozone depleting reagent, traditionally used in electrophilic, nucleophilic and carbene-type chemistry, but not as a CH2F radical source. By circumventing the challenges associated with the high reduction potential of CH2FI being closer to CH3I than CF3I, and harnessing instead the favourable bond dissociation energy of the C-I bond, we demonstrate that feedstock electron-deficient alkenes are converted into products resulting from net hydrofluoromethylation with the intervention of (Me3Si)3SiH under blue LED activation. This deceptively simple yet powerful methodology was extended to a range of (halo)methyl radical precursors including ICH2I, ICH2Br, ICH2Cl, and CHBr2F, as well as CH3I itself; this latter reagent therefore enables direct hydromethylation. This versatile chemistry was applied to18F-,13C-, and D-labelled reagents as well as complex biologically relevant alkenes, providing facile access to more than fifty products for applications in medicinal chemistry and positron emission tomography.

A one pot protocol to convert nitro-arenes into: N-aryl amides

A two-step one pot, experimentally simple protocol, based on readily available and inexpensive reagents allowed the conversion of nitro-arenes directly to N-aryl amides. A metal-free reduction of the nitro group, mediated by trichlorosilane, followed by the addition of an anhydride afforded the corresponding N-aryl carboxyamide, that was isolated after a simple aqueous work up in good-excellent yields. When the methodology was applied to the reaction with γ-butyrolactone, the desired N-aryl butanamide derivative was obtained, featuring a chlorine atom at the γ-position, a functionalized handle that can be used for further synthetic manipulation of the reaction product. Such an intermediate has already been employed as a key advanced precursor of pharmaceutically active compounds.

Alkylboronic esters from copper-catalyzed borylation of primary and secondary alkyl halides and pseudohalides

Easy access: An unprecedented copper-catalyzed cross-coupling reaction of the title compounds with diboron reagents is described (see scheme; Ts=4-toluenesulfonyl). This reaction can be used to prepare both primary and secondary alkylboronic esters having diverse structures and functional groups. The resulting products would be difficult to access by other means. Copyright